J L Snoep, H V Westerhoff, J M Rohwer, J H S Hofmeyr
{"title":"Is there an optimal ribosome concentration for maximal protein production?","authors":"J L Snoep, H V Westerhoff, J M Rohwer, J H S Hofmeyr","doi":"10.1049/ip-syb:20060023","DOIUrl":null,"url":null,"abstract":"<p><p>A core model is presented for protein production in Escherichia coli to address the question whether there is an optimal ribosomal concentration for non-ribosome protein production. Analysing the steady-state solution of the model over a range of mRNA concentrations, indicates that such an optimum ribosomal content exists, and that the optimum shifts to higher ribosomal contents at higher specific growth rates.</p>","PeriodicalId":87457,"journal":{"name":"Systems biology","volume":"153 5","pages":"398-400"},"PeriodicalIF":0.0000,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1049/ip-syb:20060023","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Systems biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1049/ip-syb:20060023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
A core model is presented for protein production in Escherichia coli to address the question whether there is an optimal ribosomal concentration for non-ribosome protein production. Analysing the steady-state solution of the model over a range of mRNA concentrations, indicates that such an optimum ribosomal content exists, and that the optimum shifts to higher ribosomal contents at higher specific growth rates.
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