{"title":"Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles.","authors":"Jun Motoyama, Noriyuki Yamashita, Tomio Morino, Masashi Tanaka, Takeshi Kobayashi, Hiroyuki Honda","doi":"10.1186/1477-044X-6-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). In this study, the in vivo effect of hyperthermia mediated by MCLs was examined using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model.</p><p><strong>Method: </strong>MCLs were injected into the mammary cancer and then subjected to an AMF.</p><p><strong>Results: </strong>Four rats in 20 developed mammary tumors at more than 1 site in the body. The first-developed tumor in each of these 4 rats was selected and heated to over 43 degrees C following administration of MCLs by an infusion pump. After a series of 3 hyperthermia treatments, treated tumors in 3 of the 4 rats were well controlled over a 30-day observation period. One of the 4 rats exhibited regrowth after 2 weeks. In this rat, there were 3 sites of tumor regrowth. Two of these regrowths were reduced in volume and regressed completely after 31 days, although the remaining one grew rapidly. These results indicated hyperthermia-induced immunological antitumor activity mediated by the MCLs.</p><p><strong>Conclusion: </strong>Our results suggest that hyperthermic treatment using MCLs is effective in a spontaneous cancer model.</p>","PeriodicalId":8888,"journal":{"name":"Biomagnetic Research and Technology","volume":"6 ","pages":"2"},"PeriodicalIF":0.0000,"publicationDate":"2008-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1477-044X-6-2","citationCount":"42","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomagnetic Research and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1477-044X-6-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 42
Abstract
Background: We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). In this study, the in vivo effect of hyperthermia mediated by MCLs was examined using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model.
Method: MCLs were injected into the mammary cancer and then subjected to an AMF.
Results: Four rats in 20 developed mammary tumors at more than 1 site in the body. The first-developed tumor in each of these 4 rats was selected and heated to over 43 degrees C following administration of MCLs by an infusion pump. After a series of 3 hyperthermia treatments, treated tumors in 3 of the 4 rats were well controlled over a 30-day observation period. One of the 4 rats exhibited regrowth after 2 weeks. In this rat, there were 3 sites of tumor regrowth. Two of these regrowths were reduced in volume and regressed completely after 31 days, although the remaining one grew rapidly. These results indicated hyperthermia-induced immunological antitumor activity mediated by the MCLs.
Conclusion: Our results suggest that hyperthermic treatment using MCLs is effective in a spontaneous cancer model.
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