[Safety and immunogenicity of measles attenuated live vaccine prepared by master seed lot vaccine of Shanghai-191 strain].

中国疫苗和免疫 Pub Date : 2009-10-01

Shu-Jun Zhang, Qi-You Xiao, Fang-Jun Li

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Abstract

Objective: To evaluate the safety and immunogenicity of a new measles vaccine prepared by master seed lot original vaccine of Shanghai-191 strain.

Methods: According to selection and exclusion criteria, 8-10-month healthy children, who have no history of measles, measles vaccine inoculation and vaccination contraindication were selected. The children selected were vaccinated 0.5 ml measles attenuate live vaccine prepared by master seed lot vaccine of the Shanghai-191 strain. They were observed the local and systemic response in 30 min and 6h, 24h, 48h, 72h, 7d, 14d, 21d, 28d after inoculation, and immune serum were collected before immunization and after 28 days. Measles virus antibody positive rate and geometric mean titer (GMT) were detected by hemagglutination inhibition.

Results: There were not serious adverse reactions. Measles virus antibodies in serum positive rate was 100% after 28 days of immunization, and measles virus antibody GMT was 1:50.66.

Conclusion: New measles vaccine prepared by master seed lot original vaccine of the Shanghai-191 strain at 8-10-month children was safe and immunogenicity.

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[上海191株主苗苗制备麻疹减毒活疫苗的安全性和免疫原性]。

目的:评价上海191株主种子原疫苗制备的麻疹新疫苗的安全性和免疫原性。方法:根据筛选和排除标准，选取8 ~ 10月龄健康、无麻疹病史、无麻疹疫苗接种和接种禁忌症的儿童。选用上海-191株主种子批疫苗配制的麻疹减毒活疫苗0.5 ml接种。分别于接种后30min、6h、24h、48h、72h、7d、14d、21d、28d观察局部和全身反应，接种前和接种后28d采集免疫血清。血凝抑制法检测麻疹病毒抗体阳性率和几何平均滴度(GMT)。结果:无严重不良反应。免疫28 d后血清麻疹病毒抗体阳性率为100%，麻疹病毒抗体GMT为1:50.66。结论:采用上海-191株主种子原疫苗制备的8-10月龄儿童麻疹新疫苗具有安全性和免疫原性。

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中国疫苗和免疫

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