{"title":"[Serum antibody response to different doses of hepatitis B vaccine made by recombinant DNA techniques in yeast and Hansenula polymorpha yeast].","authors":"Jing Sun, Yue Han, Yan Wang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To observe the serum antibody response of the population, whose hepatitis B virus surface antigen(HBsAg), antibody to hepatitis B virus surface antigen (Anti-HBs), antibody to hepatitis B virus core antigen (Anti-HBc) are all negative to the different doses of Hepatitis B vaccine made by recombinant DNA techniques in Yeast and Hansenula Polymorpha Yeast.</p><p><strong>Methods: </strong>Collecting the blood of population vaccinated after 28 to 45 days, the serological method was used to detect Anti-HBs.</p><p><strong>Results: </strong>The Anti-HBs positive rate and GMC of 5 microg HepB-Y in the population <16 years old whose HBsAg, Anti-HBs, Anti-HBc negative are 97.23% and 199.26 mlU/ml, the Anti-HBs positive rate and GMC of 10 microg HepB-HPY are 100.00% and 270.71 mlU/ml, the Anti-HBs positive rate and GMC both have significant difference. The Anti-HBs positive rate and GMC of 10 microg HepB-Y in the population > or =16 years old whose HBsAg, Anti-HBs, Anti-HBc negative are 88.72% and 101.19 mlU/ml. Anti-HBs positive rate and GMC of 10 microg HepB-HPY are 94.20% and 162.17 mlU/ml, the Anti-HBs positive rate and GMC both have significant difference.</p><p><strong>Conclusions: </strong>The population whose HBsAg, Anti-HBs, Anti-HBc negative vaccinated by HepB-Y, HepB-HPY can get better Anti-HBs response. The population younger than sixteen years old vaccinated by 10 microg HepB-HPY can get Anti-HBs positive rate and GMC higher than vaccinated by 5 microg HepB-Y. The Anti-HBs response of HepB-HPY is better than HepB-Y in the population > or =16 years old.</p>","PeriodicalId":56402,"journal":{"name":"中国疫苗和免疫","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国疫苗和免疫","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To observe the serum antibody response of the population, whose hepatitis B virus surface antigen(HBsAg), antibody to hepatitis B virus surface antigen (Anti-HBs), antibody to hepatitis B virus core antigen (Anti-HBc) are all negative to the different doses of Hepatitis B vaccine made by recombinant DNA techniques in Yeast and Hansenula Polymorpha Yeast.
Methods: Collecting the blood of population vaccinated after 28 to 45 days, the serological method was used to detect Anti-HBs.
Results: The Anti-HBs positive rate and GMC of 5 microg HepB-Y in the population <16 years old whose HBsAg, Anti-HBs, Anti-HBc negative are 97.23% and 199.26 mlU/ml, the Anti-HBs positive rate and GMC of 10 microg HepB-HPY are 100.00% and 270.71 mlU/ml, the Anti-HBs positive rate and GMC both have significant difference. The Anti-HBs positive rate and GMC of 10 microg HepB-Y in the population > or =16 years old whose HBsAg, Anti-HBs, Anti-HBc negative are 88.72% and 101.19 mlU/ml. Anti-HBs positive rate and GMC of 10 microg HepB-HPY are 94.20% and 162.17 mlU/ml, the Anti-HBs positive rate and GMC both have significant difference.
Conclusions: The population whose HBsAg, Anti-HBs, Anti-HBc negative vaccinated by HepB-Y, HepB-HPY can get better Anti-HBs response. The population younger than sixteen years old vaccinated by 10 microg HepB-HPY can get Anti-HBs positive rate and GMC higher than vaccinated by 5 microg HepB-Y. The Anti-HBs response of HepB-HPY is better than HepB-Y in the population > or =16 years old.