Hepatitis C virus genotype 3a with phylogenetically distinct origin is circulating in Pakistan.

Irshad-Ur Rehman, Muhammad Idrees, Muhammad Ali, Liaqat Ali, Sadia Butt, Abrar Hussain, Haji Akbar, Samia Afzal
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引用次数: 32

Abstract

Background: Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan.

Findings: The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis.

Conclusion: The nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.

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具有不同起源的基因型3a型丙型肝炎病毒在巴基斯坦流行。
背景:丙型肝炎病毒(HCV)是世界范围内病毒性肝炎的主要原因之一,其基因型3a在巴基斯坦广大地区占主导地位。研究结果:本研究报道了来自巴基斯坦的HCV 3a分离株PK-1的首个完整序列。采用系统发育分析的统计方法,将该核苷酸序列与来自世界不同地区的其他6条HCV基因型3a全长序列进行比较。结论:这7个序列的核苷酸差异表明HCV基因型3a在巴基斯坦流行。
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