Irshad-Ur Rehman, Muhammad Idrees, Muhammad Ali, Liaqat Ali, Sadia Butt, Abrar Hussain, Haji Akbar, Samia Afzal
{"title":"Hepatitis C virus genotype 3a with phylogenetically distinct origin is circulating in Pakistan.","authors":"Irshad-Ur Rehman, Muhammad Idrees, Muhammad Ali, Liaqat Ali, Sadia Butt, Abrar Hussain, Haji Akbar, Samia Afzal","doi":"10.1186/1479-0556-9-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan.</p><p><strong>Findings: </strong>The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis.</p><p><strong>Conclusion: </strong>The nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.</p>","PeriodicalId":12596,"journal":{"name":"Genetic Vaccines and Therapy","volume":"9 1","pages":"2"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1479-0556-9-2","citationCount":"32","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetic Vaccines and Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1479-0556-9-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 32
Abstract
Background: Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan.
Findings: The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis.
Conclusion: The nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.