Mitochondrial DNA analysis of an immigrant Basque population: loss of diversity due to founder effects.

IF 2.6 2区 地球科学 Q1 ANTHROPOLOGY American journal of physical anthropology Pub Date : 2011-04-01 Epub Date: 2010-12-01 DOI:10.1002/ajpa.21432
Michael C Davis, Stephen J Novak, Greg Hampikian
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引用次数: 8

Abstract

The Basques have a well-documented history of migration and settlement in the Americas, and they often retain cultural identity across generations. Numerous genetic studies have been carried out on European Basques; thus, immigrant Basques are an ideal population for investigating the genetic consequences of a recent human migration event. We have sampled 53 unrelated individuals with Basque ancestry in Boise, Idaho and determined the mitochondrial DNA (mtDNA) sequence variation of the first and second hypervariable regions. Thirty-six mtDNA haplotypes were detected in our sample. We found evidence of genetic changes consistent with founder effects, which is compatible with the known history of migration. Compared with the European Basque population, the immigrant Basques are significantly different in terms of haplogroup frequency distribution and diversity. They have a lower measure of weighted intralineage mean pairwise diversity (WIMP) and greater genetic distance from other European populations. These data indicate that this immigrant Basque population has experienced a reduction in genetic diversity compared with the putative source population. However, this loss of diversity is not detectable using indices of demographic history such as Tajima's D and Fu's F. This study represents the first description of mtDNA diversity in an immigrant Basque population, and our findings indicate that founder effects accompanying this relatively recent migration event have shaped the genetic diversity of this population.

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移民巴斯克人的线粒体DNA分析:由于奠基人效应的多样性丧失。
巴斯克人在美洲的迁徙和定居历史有据可查,他们往往几代人都保持着自己的文化特征。对欧洲巴斯克人进行了许多遗传研究;因此,移民巴斯克人是研究最近人类迁移事件的遗传后果的理想人群。我们在爱达荷州博伊西取样了53名无血缘关系的巴斯克血统个体,并确定了第一和第二高变区的线粒体DNA (mtDNA)序列变异。在我们的样本中检测到36个mtDNA单倍型。我们发现了与奠基人效应一致的基因变化的证据,这与已知的迁徙历史是一致的。与欧洲巴斯克人相比,移民巴斯克人在单倍群频率分布和多样性方面存在显著差异。他们的加权系内平均两两多样性(WIMP)较低,与其他欧洲人群的遗传距离更大。这些数据表明,与假定的源人群相比,移民巴斯克人群的遗传多样性有所减少。然而,使用人口统计学历史指标(如Tajima的D和Fu的f)无法检测到这种多样性的丧失。这项研究首次描述了巴斯克移民群体的mtDNA多样性,我们的研究结果表明,伴随这一相对较近的移民事件的创始人效应塑造了该群体的遗传多样性。
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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
3
审稿时长
3-8 weeks
期刊介绍: The American Journal of Physical Anthropology (AJPA) is the official journal of the American Association of Physical Anthropologists. The Journal is published monthly in three quarterly volumes. In addition, two supplements appear on an annual basis, the Yearbook of Physical Anthropology, which publishes major review articles, and the Annual Meeting Issue, containing the Scientific Program of the Annual Meeting of the American Association of Physical Anthropologists and abstracts of posters and podium presentations. The Yearbook of Physical Anthropology has its own editor, appointed by the Association, and is handled independently of the AJPA. As measured by impact factor, the AJPA is among the top journals listed in the anthropology category by the Social Science Citation Index. The reputation of the AJPA as the leading publication in physical anthropology is built on its century-long record of publishing high quality scientific articles in a wide range of topics.
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