[Cancer stem cells].

Bulletin et memoires de l'Academie royale de medecine de Belgique Pub Date : 2011-01-01

J Boniver, M Michaël Herfs

{"title":"[Cancer stem cells].","authors":"J Boniver, M Michaël Herfs","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In tumours, a significant fraction of neoplastic cells are engaged in the cell cycle (growth fraction) and are therefore targets for radiation therapy and chemotherapy. Unfortunately, in most disseminated cancers, such treatments cannot lead to complete cure. Many different mechanisms have been described to explain this resistance. The hypothesis of the existence of \"cancer stem cells \"has been recently proposed. Indeed, the tumour would contain a small subpopulation of cancer cells displaying the phenotypical characteristics of multipotential stem cells. Since such cells display different signalling pathways compared with more differentiated cells, this might explain at least partially the resistance to treatments. Chronic myeloid leukaemia is a good model in favour of cancer stem cells, but the presence of such cells in all types of cancers is still a matter of debate. Several questions emerge: is the multipotential stem cell, the cell of origin of cancer? What is the relevance of the cancer stem cell paradigm for understanding cancer cell biology and to envision new therapeutic, hopefully curative, therapies? The case of chronic myeloid leukaemia is used to discuss these questions.</p>","PeriodicalId":75641,"journal":{"name":"Bulletin et memoires de l'Academie royale de medecine de Belgique","volume":"166 3-4","pages":"141-5; discussion 146"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin et memoires de l'Academie royale de medecine de Belgique","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

In tumours, a significant fraction of neoplastic cells are engaged in the cell cycle (growth fraction) and are therefore targets for radiation therapy and chemotherapy. Unfortunately, in most disseminated cancers, such treatments cannot lead to complete cure. Many different mechanisms have been described to explain this resistance. The hypothesis of the existence of "cancer stem cells "has been recently proposed. Indeed, the tumour would contain a small subpopulation of cancer cells displaying the phenotypical characteristics of multipotential stem cells. Since such cells display different signalling pathways compared with more differentiated cells, this might explain at least partially the resistance to treatments. Chronic myeloid leukaemia is a good model in favour of cancer stem cells, but the presence of such cells in all types of cancers is still a matter of debate. Several questions emerge: is the multipotential stem cell, the cell of origin of cancer? What is the relevance of the cancer stem cell paradigm for understanding cancer cell biology and to envision new therapeutic, hopefully curative, therapies? The case of chronic myeloid leukaemia is used to discuss these questions.

微信好友朋友圈 QQ好友复制链接

本刊更多论文

[癌症干细胞]。

在肿瘤中，很大一部分肿瘤细胞参与细胞周期(生长部分)，因此是放疗和化疗的靶点。不幸的是，在大多数播散性癌症中，这种治疗不能导致完全治愈。已经描述了许多不同的机制来解释这种抗性。“癌症干细胞”存在的假说最近被提出。事实上，肿瘤可能包含一小部分癌细胞亚群，它们表现出多潜能干细胞的表型特征。由于这些细胞与分化程度更高的细胞相比表现出不同的信号传导途径，这可能至少部分解释了对治疗的抵抗。慢性髓性白血病是支持癌症干细胞的一个很好的模型，但是这种细胞在所有类型的癌症中的存在仍然是一个争论的问题。几个问题出现了:多潜能干细胞是癌症的起源细胞吗?癌症干细胞范式对于理解癌细胞生物学和设想新的治疗方法，有希望治愈的治疗方法的相关性是什么?本文以慢性髓性白血病为例来讨论这些问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Bulletin et memoires de l'Academie royale de medecine de Belgique

自引率

0.00%

发文量

期刊最新文献

[Belgium Royal Academy of Medicine membership list]. [Music, composers and psychopathology: the psychiatrist's view]. [Contributions of immunogenic cell death to the efficacy of anticancer chemotherapy]. [Cancer stem cells]. [Surgical treatment of female stress urinary incontinence: where are we in 2011?].