Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine Pub Date : 2012-12-01 DOI:10.3736/jcim20121223

Shyam Kaulaskar, Pravinkumar Bhutada, Anand Rahigude, Dilpesh Jain, Uday Harle

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引用次数: 34

Abstract

Objective: To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.

Methods: After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.

Results: Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.

Conclusion: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.

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柚皮素对慢性缩窄性神经性疼痛大鼠异常性痛和痛觉过敏的影响。

目的:研究柚皮素对神经性疼痛慢性收缩损伤(CCI)模型的镇痛作用。方法:CCI诱导神经性疼痛后，分别给予柚皮素25、50 mg/kg和普瑞巴林10 mg/kg治疗。分别于第0、3、5、7、14、21天采用哈格里夫斯热痛觉过敏仪、针刺针刺触觉机械痛觉过敏试验和冷水致异位性痛进行行为学测试。研究结束时，测定氧化应激参数。结果:柚皮素对cci致大鼠神经性疼痛均有改善作用。柚皮素还能降低脂质过氧化和一氧化氮的升高，恢复还原型谷胱甘肽的水平。结论:柚皮素在坐骨神经损伤模型中具有镇痛作用。

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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

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