A pilot study of the effects of meditation on regional brain metabolism in distressed dementia caregivers.

Aging health Pub Date : 2012-10-01 DOI:10.2217/ahe.12.46

Kelsey L Pomykala, Daniel Hs Silverman, Cheri L Geist, Patricia Voege, Prabha Siddarth, Nora Nazarian, Natalie M St Cyr, Dharma S Khalsa, Helen Lavretsky

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引用次数: 19

Abstract

AIMS: Caregiver distress can affect mood and cognition. Meditation can be used to reduce stress. This pilot study explored whether yogic meditation could change regional cerebral metabolism in distressed caregivers. METHODS: Nine dementia caregivers were randomized to undergo meditation training compared with relaxation for 12 min per day for 8 weeks. Caregivers received neuropsychiatric assessments and brain FDG-PET scans at baseline and postintervention. RESULTS: The groups did not differ on measures of mood, mental and physical health, and burden at baseline and follow-up. When comparing the regional cerebral metabolism between groups, significant differences over time were found in the bilateral cerebellum (p < 0.0005), right inferior lateral anterior temporal (p < 0.0005), right inferior frontal (p = 0.001), left superior frontal (p = 0.001), left associative visual (p = 0.002) and right posterior cingulate (p = 0.002) cortices. CONCLUSION: Meditation practice in distressed caregivers resulted in different patterns of regional cerebral metabolism from relaxation. These pilot results should be replicated in a larger study.

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冥想对痛苦痴呆护理者区域脑代谢影响的初步研究。

目的:照顾者苦恼会影响情绪和认知。冥想可以用来减轻压力。这项初步研究探讨了瑜伽冥想是否可以改变痛苦照顾者的区域脑代谢。方法:9名痴呆症护理人员随机接受冥想训练，与放松训练相比，每天12分钟，持续8周。护理人员在基线和干预后接受神经精神评估和脑FDG-PET扫描。结果:两组在基线和随访时的情绪、精神和身体健康以及负担方面没有差异。在比较两组脑区域代谢时，发现双侧小脑(p < 0.0005)、右侧颞叶下外侧前部(p < 0.0005)、右侧额叶下皮层(p = 0.001)、左侧额叶上皮层(p = 0.001)、左侧联想视觉皮层(p = 0.002)和右侧扣带后皮层(p = 0.002)随时间的变化存在显著差异。结论:冥想练习对痛苦照护者产生不同于放松的区域脑代谢模式。这些试点结果应该在更大规模的研究中得到重复。

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Aging health

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