Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2014-04-01 DOI:10.1186/1476-511X-13-60

Sanaa Ouatou, Maria Ajjemami, Hicham Charoute, Hajar Sefri, Noreddine Ghalim, Houria Rhaissi, Houda Benrahma, Abdelhamid Barakat, Hassan Rouba

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引用次数: 1

Abstract

Background: The goal of the study is to investigate the association between the APOA5 polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients.

Methods: The study was performed in 283 subjects, 149 patients with AHT and 134 controls. All subjects were genotyped for the APOA5 -1131 T > C (rs662799), 56C > G (rs3135506) and c.553G > T (rs2075291) polymorphisms.

Results: There was a strong association between -1131 T > C and 56C > G polymorphisms with AHT. The -1131 T > C and 56C > G polymorphisms were significantly associated with increased systolic blood pressure (SBP) and triglycerides (TG) levels. There were 4 haplotypes with a frequency higher than 5%, constructed from APOA5 polymorphisms, with the following order: -1131 T > C, 56C > G and c.553G > T. Haplotype H1 (TCG) was associated with decreased risk of AHT, whereas the haplotypes H2 (CCG) and H4 (CGG) were significantly associated with an increased risk of AHT. Carriers of H1 haplotype had a lower SBP and DBP and TG. In contrast, significant elevated SBP, DBP and TG were found in H4 haplotypes carriers.

Conclusions: Our data demonstrate for the first time that several common SNPs in the APOA5 gene and their haplotypes are closely associated with modifications of blood pressure and serum lipid parameters in the AHT patient.

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APOA5 rs662799和rs3135506多态性与摩洛哥高血压患者的关系

背景:本研究的目的是调查APOA5多态性和单倍型与摩洛哥患者动脉高血压(AHT)之间的关系。方法:283例被试，149例AHT患者，134例对照。对所有受试者进行APOA5 -1131 T > C (rs662799)、56C > G (rs3135506)和C . 553g > T (rs2075291)多态性的基因分型。结果:-1131 T > C和56C > G多态性与AHT有较强的相关性。-1131 T > C和56C > G多态性与收缩压(SBP)和甘油三酯(TG)水平升高显著相关。由APOA5多态性构建的单倍型中，频率高于5%的有4个，顺序为:-1131 T > C、56C > G和C . 553g > T。单倍型H1 (TCG)与AHT风险降低相关，而单倍型H2 (CCG)和H4 (CGG)与AHT风险增加显著相关。H1单倍型携带者的收缩压、舒张压和TG均较低。相比之下，H4单倍型携带者的收缩压、舒张压和TG显著升高。结论:我们的数据首次证明APOA5基因中的几个常见snp及其单倍型与AHT患者血压和血脂参数的改变密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.