The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-06-01 DOI:10.1590/0004-2730000003050

Jakeline Rheinheimer, Fernanda dos Santos de Oliveira, Luís Henrique Canani, Daisy Crispim

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引用次数: 6

Abstract

Objective: To evaluate the association of the PTPN2 rs1893217 polymorphism with T1DM and/or its clinical and laboratory characteristics in a Caucasian population from Southern Brazil.

Subjects and methods: Four hundred and eighty six patients with T1DM and 484 non-diabetic subjects were included in the study. Genotyping of the PTPN2 rs1893217 was performed by real-time PCR.

Results: Genotype frequencies did not differ between T1DM patients and non-diabetic subjects (P = 0.265). The C allele was observed in 14.5% of the T1DM sample and 12.2% of the non-diabetic group (P = 0.152). Moreover, the frequencies of this variant did not differ statistically between T1DM patients and non-diabetic subjects when assuming recessive, dominant, or additive inheritance models. The clinical and laboratory characteristics of T1DM patients did not differ significantly among the three genotypes of the rs1893217 polymorphism, either.

Conclusion: The PTPN2 rs1893217 polymorphism is not significantly associated with T1DM in Caucasian subjects from Southern Brazil.

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PTPN2基因rs1893217 (T/C)多态性与巴西南部受试者的1型糖尿病无关。

目的:评估PTPN2 rs1893217多态性与巴西南部高加索人群T1DM和/或其临床和实验室特征的关系。对象和方法:纳入486例T1DM患者和484例非糖尿病患者。采用实时荧光定量PCR对PTPN2 rs1893217进行基因分型。结果:基因型频率在T1DM患者和非糖尿病患者之间没有差异(P = 0.265)。14.5%的T1DM组和12.2%的非糖尿病组存在C等位基因(P = 0.152)。此外，当采用隐性、显性或加性遗传模型时，该变异的频率在T1DM患者和非糖尿病患者之间没有统计学差异。rs1893217多态性的三种基因型在T1DM患者的临床和实验室特征上也没有显著差异。结论:PTPN2 rs1893217多态性与巴西南部高加索人群T1DM无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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