Present and possible therapies for age-related macular degeneration.

ISRN ophthalmology Pub Date : 2014-04-16 eCollection Date: 2014-01-01 DOI:10.1155/2014/608390
Muhammad Khan, Ketan Agarwal, Mohamed Loutfi, Ahmed Kamal
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引用次数: 27

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly population worldwide and is defined as a chronic, progressive disorder characterized by changes occurring within the macula reflective of the ageing process. At present, the prevalence of AMD is currently rising and is estimated to increase by a third by 2020. Although our understanding of the several components underpinning the pathogenesis of this condition has increased significantly, the treatment options for this condition remain substantially limited. In this review, we outline the existing arsenal of therapies available for AMD and discuss the additional role of further novel therapies currently under investigation for this debilitating disease.

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老年性黄斑变性目前及可能的治疗方法。
年龄相关性黄斑变性(老年性黄斑变性,AMD)是全球老年人失明的最常见原因,被定义为一种慢性进行性疾病,其特征是黄斑内发生的变化反映了衰老过程。目前,AMD的患病率正在上升,预计到2020年将增加三分之一。尽管我们对这种疾病发病机制的几个组成部分的理解已经大大增加,但这种疾病的治疗选择仍然非常有限。在这篇综述中,我们概述了现有的可用于AMD的治疗方法,并讨论了目前正在研究的用于这种使人衰弱的疾病的进一步新疗法的额外作用。
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