Diagnosis and management of Paget's disease of bone.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-08-01 DOI:10.1590/0004-2730000002941

Luiz Griz, Daniele Fontan, Patricia Mesquita, Marise Lazaretti-Castro, Victoria Zeghbi Cochenski Borba, João Lindolfo Cunha Borges, Thyciara Fontenele, Juliana Maia, Francisco Bandeira

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引用次数: 21

Abstract

Objective: To conduct a literature review on the diagnosis and management of Paget's disease of bone.

Materials and methods: This scientific statement was generated by a request from the Brazilian Medical Association (AMB) to the Brazilian Society of Endocrinology and Metabolism (SBEM) as part of its Clinical Practice Guidelines program. Articles were identified by searching in PubMed and Cochrane databases as well as abstracts presented at the Endocrine Society, Brazilian Society for Endocrinology Annual Meetings and the American Society for Bone and Mineral Research Annual Meeting during the last 5 years. Grading quality of evidence and strength of recommendation were adapted from the first report of the Oxford Centre for Evidence-based Medicine. All grades of recommendation, including "D", are based on scientific evidence. The differences between A, B, C and D, are due exclusively to the methods employed in generating evidence.

Conclusion: We present a scientific statement on Paget's disease of bone providing the level of evidence and the degree of recommendation regarding causes, clinical presentation as well as surgical and medical treatment.

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骨佩吉特病的诊断和治疗。

目的:对骨Paget病的诊断和治疗进行文献综述。材料和方法:本科学声明是应巴西医学协会(AMB)向巴西内分泌与代谢学会(SBEM)的要求生成的，作为其临床实践指南计划的一部分。通过检索PubMed和Cochrane数据库以及近5年内分泌学会、巴西内分泌学会年会和美国骨与矿物研究学会年会上发表的摘要来确定文章。证据质量和推荐强度的分级改编自牛津循证医学中心的第一份报告。所有等级的推荐，包括“D”，都是基于科学证据的。A、B、C和D之间的差异完全是由于产生证据所采用的方法不同。结论:我们提出了一份关于骨佩吉特病的科学声明，提供了关于病因、临床表现以及手术和药物治疗的证据水平和推荐程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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