Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion.

Rogelio Trejo-Rosales, Maria J Nevarez-Barragan, Mercedes G Rosas-Jurado, Ivan Perez-Diaz, Ana Paula Piana Bezaury
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引用次数: 1

Abstract

We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC). A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.

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阴茎鳞状细胞癌与甲状旁腺相关肽(PTH-rP)分泌的罕见关联。
我们报告一例罕见的成人严重高钙血症继发于异位分泌甲状旁腺相关肽(PTH-rP)从阴茎鳞状细胞癌(PC)。患者47岁,因腹股沟、阴囊和阴茎大面积出现疣状病变和脓性物质覆盖的溃疡而入院。实验室检查显示严重的高钙血症和PTH-rP升高;活检报告PC。唑来膦酸成功治疗了高钙血症,然而,肿瘤表现出侵袭性行为,导致患者预后不良。
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[Multiple endocrine neoplasia type 2]. [Thyroid hormone resistance syndrome]. A case of thyroid hormone resistance: a rare mutation. [Giant metastasis of thyroid papillar carcinoma]. Angiotensin-II induced insulin resistance.
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