The preventive effect of β3 adrenoceptor stimulation against experimentally induced reflux esophagitis.

Acta physiologica Hungarica Pub Date : 2015-03-01 DOI:10.1556/APhysiol.102.2015.1.10

Hala Abdel Malek, A Shalaby

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Abstract

Unlabelled: A β3 adrenoceptor agonist plays an important regulatory role in stimulation of thermogenesis and lipolysis and it appears to have anti-ulcer and spasmolytic effects. So the present aim was to examine the effect of BRL 37344 (a selective B3 adrenoceptor agonist) on reflux esophagitis.

Methods: Forty-eight rats were divided into twelve sham-operated with BRL 37344 and/or omeprazole with or without indomethacin. RE was induced in rats, then gastric acid output, pH, plasma nitric oxide (NO), esophageal PGE2, malondialdehyde (MDA) and reduced glutathione (GSH) were measured and the esophageal injury was assessed by macroscopic damage score.

Results: Pretreatment with BRL significantly increased plasma NO, GSH, decreased acid output, esophageal MDA and esophageal injury in comparison to pretreatment. In addition, there was a no significant increase in esophageal PGE2.

Conclusion: It can be concluded that BRL 37344 has an anti-oxidant protective effect in rats with RE.

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β3肾上腺素能受体刺激对实验性反流性食管炎的预防作用。

未标记:β3肾上腺素能受体激动剂在刺激产热和脂肪分解中起重要的调节作用，它似乎具有抗溃疡和解痉作用。因此，目前的目的是研究BRL 37344(一种选择性B3肾上腺素受体激动剂)对反流性食管炎的影响。方法:48只大鼠随机分为12只，分别用BRL 37344和/或奥美拉唑加或不加吲哚美辛进行假手术。采用RE诱导大鼠，测定胃酸输出量、pH、血浆一氧化氮(NO)、食管PGE2、丙二醛(MDA)、还原性谷胱甘肽(GSH)，并采用宏观损伤评分法评价食管损伤。结果:与预处理相比，BRL预处理显著提高了血浆NO、GSH，降低了酸输出量、食管MDA和食管损伤。此外，食管PGE2无明显升高。结论:BRL 37344对RE大鼠具有抗氧化保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta physiologica Hungarica 医学-生理学

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6.0 months