Considerations of biomarker application for cancer continuum in the era of precision medicine.

3区 医学 Current Epidemiology Reports Pub Date : 2022-09-01 Epub Date: 2022-07-09 DOI:10.1007/s40471-022-00295-8
Rayjean J Hung, Elham Khodayari Moez, Shana J Kim, Sanjeev Budhathoki, Jennifer D Brooks
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Abstract

Purpose of the review: The goal of this review is to highlight emerging biomarker research by the key phases of the cancer continuum and outline the methodological considerations for biomarker application.

Recent findings: While biomarkers have an established role in targeted therapy and to some extent, disease monitoring, their role in early detection and survivorship remains to be elucidated. With the advent of omics technology, the discovery of biomarkers has been accelerated exponentially, therefore careful consideration to ensure an unbiased study design and robust validity is crucial.

Summary: The rigor of biomarker research holds the key to the success of precision health care. The potential clinical utility and the feasibility of implementation should be central to future biomarker research study design.

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精准医疗时代癌症连续性生物标记应用的考虑因素。
综述的目的:本综述的目的是按癌症持续发展的关键阶段重点介绍新出现的生物标志物研究,并概述生物标志物应用的方法学注意事项:虽然生物标志物在靶向治疗和一定程度上的疾病监测中发挥着既定的作用,但它们在早期检测和生存方面的作用仍有待阐明。摘要:生物标记物研究的严谨性是精准医疗成功的关键。潜在的临床效用和实施的可行性应成为未来生物标志物研究设计的核心。
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Current Epidemiology Reports
Current Epidemiology Reports OTORHINOLARYNGOLOGY-
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