Updates on Histoplasmosis in Solid Organ Transplantation.

IF 2.3 Q3 INFECTIOUS DISEASES Current Fungal Infection Reports Pub Date : 2022-01-01 Epub Date: 2022-09-08 DOI:10.1007/s12281-022-00441-1

Jennifer L Saullo, Rachel A Miller

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引用次数: 3

Abstract

Purpose of review: Histoplasmosis remains a challenging infection in solid organ transplantation. This review provides a topic update with emphasis on the changing Histoplasma epidemiology, along with new diagnostic and treatment innovations.

Recent findings: Recent years have observed expanding Histoplasma geographic distribution due to climate change, environmental disruption, and host factors. Early clinical experience also suggests a relationship between COVID-19 infection and histoplasmosis, particularly among immunocompromised individuals. Advances in diagnostic methods, such as newer enzyme immunoassays and molecular techniques, have broadened the capability for expedient and highly specific pathogen identification. Novel drug innovations, including the development of new formulations of existing antifungal agents, extended-spectrum azoles and new antifungal drug classes have expanded therapeutic options.

Summary: Advances in organ transplantation have largely outpaced those for histoplasmosis. However, these emerging insights enhance our understanding of this pathogen and management of clinical infection, particularly for transplant recipients with a higher incidence and severity of disease.

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组织浆菌病在实体器官移植中的最新进展。

综述目的:组织胞浆菌病在实体器官移植中仍然是一种具有挑战性的感染。这篇综述提供了一个主题更新，重点是不断变化的组织浆体流行病学，以及新的诊断和治疗创新。最近发现:近年来，由于气候变化、环境破坏和宿主因素，组织浆体的地理分布不断扩大。早期临床经验还表明，COVID-19感染与组织胞浆菌病之间存在关系，特别是在免疫功能低下的个体中。诊断方法的进步，如较新的酶免疫测定法和分子技术，扩大了权宜之计和高度特异性病原体鉴定的能力。新的药物创新，包括现有抗真菌药物的新配方的开发，广谱唑和新的抗真菌药物类别扩大了治疗选择。摘要:器官移植的进展在很大程度上超过了组织浆菌病的进展。然而，这些新出现的见解增强了我们对这种病原体和临床感染管理的理解，特别是对于发病率和疾病严重程度较高的移植受者。

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来源期刊

Current Fungal Infection Reports INFECTIOUS DISEASES-

CiteScore

3.10

自引率

7.10%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of fungal infections. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as advances in diagnosis, current and emerging management approaches, and genomics and pathogenesis. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. Commentaries from well-known figures in the field are also provided, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.