Pub Date : 2023-10-17DOI: 10.1007/s12281-023-00476-y
Milena Kordalewska, David S. Perlin
Abstract Purpose of Review This review discusses the connections between the gut-lung axis, gut and respiratory tract dysbiosis, and Candida bloodstream, oral, and respiratory infections in COVID-19 patients. Recent Findings COVID-19–related dysfunction in the intestinal barrier together with gut and lung dysbiosis played an important role in disease pathophysiology, which affected host immune homeostasis giving rise to prominent systemic and respiratory bacterial and fungal infections. Higher incidence of Candida bloodstream infections driven by accumulation of “classic” risk factors in severely ill COVID-19 patients was noted. Moreover, numerous C. auris outbreaks, characterized by high clonality of the strains, were reported from all around the world. Unlike other Candida species, C. auris colonization and infection cases most likely resulted from nosocomial transmission. Summary Infections due to Candida species in severely ill COVID-19 patients reflected the overall immune dysregulation and were largely driven by gut and respiratory tract dysbiosis.
{"title":"Candida in COVID-19: Gut-Lung Axis, Dysbiosis, and Infections","authors":"Milena Kordalewska, David S. Perlin","doi":"10.1007/s12281-023-00476-y","DOIUrl":"https://doi.org/10.1007/s12281-023-00476-y","url":null,"abstract":"Abstract Purpose of Review This review discusses the connections between the gut-lung axis, gut and respiratory tract dysbiosis, and Candida bloodstream, oral, and respiratory infections in COVID-19 patients. Recent Findings COVID-19–related dysfunction in the intestinal barrier together with gut and lung dysbiosis played an important role in disease pathophysiology, which affected host immune homeostasis giving rise to prominent systemic and respiratory bacterial and fungal infections. Higher incidence of Candida bloodstream infections driven by accumulation of “classic” risk factors in severely ill COVID-19 patients was noted. Moreover, numerous C. auris outbreaks, characterized by high clonality of the strains, were reported from all around the world. Unlike other Candida species, C. auris colonization and infection cases most likely resulted from nosocomial transmission. Summary Infections due to Candida species in severely ill COVID-19 patients reflected the overall immune dysregulation and were largely driven by gut and respiratory tract dysbiosis.","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging Challenges in Diagnosis and Treatment of Invasive Fungal Infections: Addressing the Impact of COVID-19 and New Pathogens","authors":"Ali Ahmadi, Bahareh Bashardoust, Mahsa Abdorahimi, Selva Aminizadeh, Mohammadreza Salehi, Sadegh Khodavaisy","doi":"10.1007/s12281-023-00475-z","DOIUrl":"https://doi.org/10.1007/s12281-023-00475-z","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136235768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-11DOI: 10.1007/s12281-023-00473-1
Norma Olivia de la O-Escamilla, Dulce Melissa Martínez–Téllez, Miguel Ángel Sánchez-Romero, Elizabeth Esther Cortés-Salazar, Mirna Eréndira Toledo-Bahena, Carlos Alfredo Mena-Cedillos, Sonia Toussaint–Caire, Marcela Salazar–García, Adriana Valencia-Herrera, Alexandro Bonifaz
{"title":"Tinea Nigra in Children","authors":"Norma Olivia de la O-Escamilla, Dulce Melissa Martínez–Téllez, Miguel Ángel Sánchez-Romero, Elizabeth Esther Cortés-Salazar, Mirna Eréndira Toledo-Bahena, Carlos Alfredo Mena-Cedillos, Sonia Toussaint–Caire, Marcela Salazar–García, Adriana Valencia-Herrera, Alexandro Bonifaz","doi":"10.1007/s12281-023-00473-1","DOIUrl":"https://doi.org/10.1007/s12281-023-00473-1","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135981435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-27DOI: 10.1007/s12281-023-00474-0
R. Lewis, M. Stanzani
{"title":"Antifungal Prophylaxis in the Era of Targeted Chemotherapy for Acute Myelogenous Leukemia","authors":"R. Lewis, M. Stanzani","doi":"10.1007/s12281-023-00474-0","DOIUrl":"https://doi.org/10.1007/s12281-023-00474-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"250 - 261"},"PeriodicalIF":1.4,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47791729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1007/s12281-023-00468-y
Z. Pek, J. Bork
{"title":"A Scoping Review of the Changing Epidemiology and Risk Factors of Endogenous Candida Ocular Infections","authors":"Z. Pek, J. Bork","doi":"10.1007/s12281-023-00468-y","DOIUrl":"https://doi.org/10.1007/s12281-023-00468-y","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"188 - 194"},"PeriodicalIF":1.4,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41846559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-19eCollection Date: 2024-08-01DOI: 10.1159/000531234
Maria Ana Rafael, Cristiana Sequeira, Sónia Isabel da Silva Barros, Bárbara Silva Abreu, Cristina Teixeira, Pierre Lahmek, Marine Besnard, Bruno Lesgourgues
Introduction: The outbreak of coronavirus disease 2019 (COVID-19) had affected clinical practice in several ways, including the restriction of nonessential endoscopic procedures. Therefore, our aim was to evaluate how colorectal cancer (CRC) diagnosis and management was affected during the first year of pandemics in Portugal.
Methods: This is a Portuguese substudy of the French retrospective multicentric study ETICC (Etude de l'Impact de la pandémie COVID-19 sur le diagnostic et la prise en charge du Cancer Colorectal). We compared patients' characteristics, clinical manifestations, CRC staging at diagnosis, delay to first medical appointment, histological diagnosis, surgical and medical treatments between the year previous to the pandemics (control) and the first year of pandemics.
Results: We included 766 patients: 496 in the control group and 270 in the COVID group. There was no significant difference in CRC staging at diagnosis between both groups, with 21% being diagnosed as metastatic in the control group and 22% in the first year of pandemics (p = 0.770). Contrary to what happened in France, there was a significant decrease in CRC diagnosis in asymptomatic patients (25-8.4%; p < 0.001) and after a positive fecal immunochemical test (20.8-11.3%; p = 0.002) during the pandemics. Although the increase in the overall complication rate at diagnosis was nonsignificant, in Portugal, there was a significant increase in diagnosis of abdominal occlusion (12.1-18.1%; p = 0.033). In Portugal, time between the beginning of symptoms and the first medical appointment significantly increased from a median of 50 days to 64 days during COVID (p < 0.001). On the contrary, time between histological diagnosis and tumor resection had significantly decreased from a median of 65 to 39 days (p < 0.001). Time between histological diagnosis and neoadjuvant treatment was not statistically different (median of 64-67 days; p = 0.590), as was time between histological diagnosis and palliative chemotherapy (median of 50-51 days; p = 1.000). Time from CRC resection and adjuvant treatment has significantly decreased from a median of 54 to 43 days (p = 0.001).
Discussion: We found a significant impact in CRC diagnosis in the first year of pandemics, more pronounced than what was found in France. These are likely related not only with the closing of endoscopy units but also with the difficulties patients had in finding an appointment with their general practitioners. On the other hand, both in France and Portugal, the first year of pandemics did not worsen CRC staging at diagnosis and did not significantly affect medical and surgical treatments once the diagnosis was made.
导言：冠状病毒病 2019（COVID-19）的爆发在多个方面影响了临床实践，包括限制非必要的内窥镜手术。因此，我们的目的是评估葡萄牙大流行第一年期间结直肠癌（CRC）诊断和管理受到的影响：这是法国回顾性多中心研究 ETICC（Etude de l'Impact de la pandémie COVID-19 sur le diagnostic et la prise en charge du Cancer Colorectal）的葡萄牙子研究。我们比较了大流行前一年（对照组）与大流行第一年之间患者的特征、临床表现、诊断时的 CRC 分期、首次就诊时间、组织学诊断、手术和药物治疗：我们纳入了 766 名患者：对照组 496 人，COVID 组 270 人。两组患者在确诊时的癌症分期没有明显差异，对照组中有 21% 的患者被诊断为转移性癌症，而在大流行的第一年则有 22% 的患者被诊断为转移性癌症（P = 0.770）。与法国的情况相反，在大流行期间，无症状患者（25-8.4%；p < 0.001）和粪便免疫化学检验阳性患者（20.8-11.3%；p = 0.002）的 CRC 诊断率显著下降。虽然确诊时的总体并发症发生率没有显著增加，但在葡萄牙，腹腔闭塞的确诊率显著增加（12.1%-18.1%；p = 0.033）。在葡萄牙，从开始出现症状到首次就诊的时间从 COVID 期间的中位数 50 天显著增加到 64 天（p < 0.001）。相反，从组织学诊断到肿瘤切除的时间从中位数 65 天大幅缩短至 39 天（p < 0.001）。组织学诊断与新辅助治疗之间的时间无统计学差异（中位数为 64-67 天；p = 0.590），组织学诊断与姑息化疗之间的时间也无统计学差异（中位数为 50-51 天；p = 1.000）。从癌症切除到辅助治疗的时间从中位数 54 天显著缩短至 43 天（p = 0.001）：讨论：我们发现，大流行第一年对 CRC 诊断的影响很大，比在法国发现的更明显。这可能不仅与内窥镜检查机构的关闭有关，还与患者在与全科医生预约时遇到的困难有关。另一方面，在法国和葡萄牙，大流行的第一年并没有使诊断时的癌症分期恶化，也没有明显影响诊断后的内外科治疗。
{"title":"Portuguese Results of the ETICC Study: Impact of the Pandemic COVID-19 in the Diagnosis and Management of Colorectal Cancer in 2020 in Portuguese Hospitals.","authors":"Maria Ana Rafael, Cristiana Sequeira, Sónia Isabel da Silva Barros, Bárbara Silva Abreu, Cristina Teixeira, Pierre Lahmek, Marine Besnard, Bruno Lesgourgues","doi":"10.1159/000531234","DOIUrl":"10.1159/000531234","url":null,"abstract":"<p><strong>Introduction: </strong>The outbreak of coronavirus disease 2019 (COVID-19) had affected clinical practice in several ways, including the restriction of nonessential endoscopic procedures. Therefore, our aim was to evaluate how colorectal cancer (CRC) diagnosis and management was affected during the first year of pandemics in Portugal.</p><p><strong>Methods: </strong>This is a Portuguese substudy of the French retrospective multicentric study ETICC (<i>Etude de l'Impact de la pandémie COVID-19 sur le diagnostic et la prise en charge du Cancer Colorectal</i>). We compared patients' characteristics, clinical manifestations, CRC staging at diagnosis, delay to first medical appointment, histological diagnosis, surgical and medical treatments between the year previous to the pandemics (control) and the first year of pandemics.</p><p><strong>Results: </strong>We included 766 patients: 496 in the control group and 270 in the COVID group. There was no significant difference in CRC staging at diagnosis between both groups, with 21% being diagnosed as metastatic in the control group and 22% in the first year of pandemics (<i>p</i> = 0.770). Contrary to what happened in France, there was a significant decrease in CRC diagnosis in asymptomatic patients (25-8.4%; <i>p</i> < 0.001) and after a positive fecal immunochemical test (20.8-11.3%; <i>p</i> = 0.002) during the pandemics. Although the increase in the overall complication rate at diagnosis was nonsignificant, in Portugal, there was a significant increase in diagnosis of abdominal occlusion (12.1-18.1%; <i>p</i> = 0.033). In Portugal, time between the beginning of symptoms and the first medical appointment significantly increased from a median of 50 days to 64 days during COVID (<i>p</i> < 0.001). On the contrary, time between histological diagnosis and tumor resection had significantly decreased from a median of 65 to 39 days (<i>p</i> < 0.001). Time between histological diagnosis and neoadjuvant treatment was not statistically different (median of 64-67 days; <i>p</i> = 0.590), as was time between histological diagnosis and palliative chemotherapy (median of 50-51 days; <i>p</i> = 1.000). Time from CRC resection and adjuvant treatment has significantly decreased from a median of 54 to 43 days (<i>p</i> = 0.001).</p><p><strong>Discussion: </strong>We found a significant impact in CRC diagnosis in the first year of pandemics, more pronounced than what was found in France. These are likely related not only with the closing of endoscopy units but also with the difficulties patients had in finding an appointment with their general practitioners. On the other hand, both in France and Portugal, the first year of pandemics did not worsen CRC staging at diagnosis and did not significantly affect medical and surgical treatments once the diagnosis was made.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"7 1","pages":"256-261"},"PeriodicalIF":1.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74301589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.1007/s12281-023-00472-2
J. Rodríguez, Julio Roberto Hernández-Juárez, E. Corona-Rodarte, V. Muñoz‐Estrada
{"title":"Onychomycosis Caused by Fusarium Species: a Review","authors":"J. Rodríguez, Julio Roberto Hernández-Juárez, E. Corona-Rodarte, V. Muñoz‐Estrada","doi":"10.1007/s12281-023-00472-2","DOIUrl":"https://doi.org/10.1007/s12281-023-00472-2","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"233 - 238"},"PeriodicalIF":1.4,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47259808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.1007/s12281-023-00470-4
Dalviany Taques Ferreira, Priscila Vieira da Silva, Hélio Chagas Chaves de Oliveira Junior, Kellyth Andrade Pereira Rocha, D. R. Da Silva, Nayla de Souza Pitangui, Janaína de Cássia Orlandi Sardi
{"title":"Can There Be a Relationship Between Oral Candidiasis and Candidemia in ICU Patients?","authors":"Dalviany Taques Ferreira, Priscila Vieira da Silva, Hélio Chagas Chaves de Oliveira Junior, Kellyth Andrade Pereira Rocha, D. R. Da Silva, Nayla de Souza Pitangui, Janaína de Cássia Orlandi Sardi","doi":"10.1007/s12281-023-00470-4","DOIUrl":"https://doi.org/10.1007/s12281-023-00470-4","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"195 - 201"},"PeriodicalIF":1.4,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42537493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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