Numerical simulation of blood flow and plaque progression in carotid-carotid bypass patient specific case.

Q Medicine Computer Aided Surgery Pub Date : 2015-01-01 Epub Date: 2015-08-20 DOI:10.3109/10929088.2015.1076036
Nenad Filipovic, Igor Saveljic, Dalibor Nikolic, Zarko Milosevic, Pavle Kovacevic, Lazar Velicki
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引用次数: 7

Abstract

This study describes computer simulation of blood flow and plaque progression pattern in a patient who underwent surgical treatment for infected carotid prosthetic tube graft using carotid-carotid cross-over bypass. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow and is modelled by the convection-diffusion equation. Low-density lipoprotein (LDL) transport in lumen of the vessel is described by Kedem-Katchalsky equations. The inflammatory process is solved using three additional reaction-diffusion partial differential equations. Calculation based on a computer simulation showed that flow distribution in the left carotid artery (CA) was around 40-50% of the total flow in the right common CA. Also, the left CA had higher pressure gradient after surgical intervention. Plaque progression simulation predicted development of the atherosclerotic plaque in the position of the right common CA and the left internal CA. A novel way of atherosclerotic plaque progression modelling using computer simulation shows a potential clinical benefit with significant impact on the treatment strategy optimization.

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颈动脉-颈动脉搭桥术患者血流和斑块进展的数值模拟。
本研究描述了采用颈动脉-颈动脉交叉搭桥手术治疗感染颈动脉假体管的患者的血流和斑块进展模式的计算机模拟。三维血流由Navier-Stokes方程和连续性方程控制。血腔内和动脉壁的质量传递与血流相结合,并通过对流扩散方程进行建模。低密度脂蛋白(LDL)在血管腔内的运输用Kedem-Katchalsky方程描述。用三个附加的反应扩散偏微分方程求解炎症过程。计算机模拟计算显示,左侧颈动脉(CA)的流量分布约为右侧普通CA总流量的40-50%,且手术干预后左侧颈动脉的压力梯度较高。斑块进展模拟预测了右侧普通CA和左侧内部CA位置动脉粥样硬化斑块的发展。一种使用计算机模拟动脉粥样硬化斑块进展建模的新方法显示了潜在的临床益处,对治疗策略优化具有重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Computer Aided Surgery
Computer Aided Surgery 医学-外科
CiteScore
0.75
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: The scope of Computer Aided Surgery encompasses all fields within surgery, as well as biomedical imaging and instrumentation, and digital technology employed as an adjunct to imaging in diagnosis, therapeutics, and surgery. Topics featured include frameless as well as conventional stereotaxic procedures, surgery guided by ultrasound, image guided focal irradiation, robotic surgery, and other therapeutic interventions that are performed with the use of digital imaging technology.
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One-step reconstruction with a 3D-printed, biomechanically evaluated custom implant after complex pelvic tumor resection. Quantitative analysis of velopharyngeal movement using a stereoendoscope: accuracy and reliability of range images. Numerical simulation of blood flow and plaque progression in carotid-carotid bypass patient specific case. Towards the clinical integration of an image-guided navigation system for percutaneous liver tumor ablation using freehand 2D ultrasound images. A comparison of two surgical approaches in functional neurosurgery: individualized versus conventional stereotactic frames.
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