[Antitumor and Radioprotective Action of a Low-frequency Turbulent Magnetic Field].

Abstract

The results of experimental studies on the biological effects and mechanisms of action of antitumor and radio modifying weak low-frequency turbulent magnetic field (TMF) on tumor objects of different levels of integration are presented. The studies have been conducted in the Russian Cancer Research Center named after Blokhin of the Russian Academy of Medical Sciences using the methods and criteria applied for the evaluation of antitumor efficacy of new drugs and impacts. Studies of the direct TMP action on tumor cells demonstrate the inhibitory effect on the DNA synthesis, also shown is the ability of TMP to induce apoptosis. It has been shown that exposure to TMF increases the functional activity of phagocytes, which manifests itself in increased level of non-specific resistance of the organism to the tumor process, and represents one of the possible mechanisms of the antitumor action. The discovered radio modifying effect of TMP opens the prospects for its use in combination with radiotherapy. Possible hypotheses about biophysical mechanisms of the established biological effects of TMP are presented. The presence in this physical factor of its own antitumor activity can be of interest for further research.