[THE EFFECT OF PERINATAL HYPOXIA ON THE STRUCTURE OF BLOOD-BRAIN BARRIER IN RATS TREATED WITH SALIFEN].

Abstract

The work was performed on Wistar rats, which were dividedinto 3 groups: 1st group--experimental rats subjected to hypoxia and treated with salifen (15 mg/kg for 14 days), 2nd group--control rats exposed to hypoxia only without treatment, and 3rdgroup--intact animals (8-10 animals in each group). Using themethods of light and electron microscopy, the effect of salifen onthe structural characteristics of the elements of the blood-brainbarrier (BBB) in the neocortex was studied in rats after exposureto hypoxia in the early postnatal period--on postnatal Day 2(model of human preterm pregnancy). The results showed thatsalifen had a positive effect on the state of the microvasculatureafter perinatal hypoxia, in particular, on the state of endothelialcells. Its active participation in the compensatory-adaptive reactions of the BBB in response to hypoxia exposure was detected,and the prospects of further studies of the protective properties ofsalifen are emphasized.