Mathematical modeling of the female reproductive system: from oocyte to delivery.

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2017-01-01 Epub Date: 2016-09-09 DOI:10.1002/wsbm.1353
Alys R Clark, Jennifer A Kruger
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引用次数: 6

Abstract

From ovulation to delivery, and through the menstrual cycle, the female reproductive system undergoes many dynamic changes to provide an optimal environment for the embryo to implant, and to develop successfully. It is difficult ethically and practically to observe the system over the timescales involved in growth and development (often hours to days). Even in carefully monitored conditions clinicians and biologists can only see snapshots of the development process. Mathematical models are emerging as a key means to supplement our knowledge of the reproductive process, and to tease apart complexity in the reproductive system. These models have been used successfully to test existing hypotheses regarding the mechanisms of female infertility and pathological fetal development, and also to provide new experimentally testable hypotheses regarding the process of development. This new knowledge has allowed for improvements in assisted reproductive technologies and is moving toward translation to clinical practice via multiscale assessments of the dynamics of ovulation, development in pregnancy, and the timing and mechanics of delivery. WIREs Syst Biol Med 2017, 9:e1353. doi: 10.1002/wsbm.1353 For further resources related to this article, please visit the WIREs website.

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女性生殖系统的数学建模:从卵母细胞到分娩。
从排卵到分娩,以及整个月经周期,女性生殖系统经历了许多动态变化,为胚胎植入和成功发育提供了最佳环境。在涉及生长和发展的时间尺度(通常是几小时到几天)上观察系统在伦理上和实践上都是困难的。即使在精心监测的条件下,临床医生和生物学家也只能看到发育过程的快照。数学模型正在成为补充我们对生殖过程知识的关键手段,并梳理出生殖系统的复杂性。这些模型已经成功地验证了关于女性不育和胎儿病理发育机制的现有假设,并提供了关于发育过程的新的实验可验证的假设。这一新的知识使辅助生殖技术得到了改进,并通过对排卵动力学、妊娠发育、分娩时间和机制的多尺度评估,正朝着临床实践的方向发展。中国生物医学工程学报,2017,29(4):553 - 553。doi: 10.1002 / wsbm.1353有关与本文相关的更多资源,请访问WIREs网站。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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