Tools for computational analysis of moving boundary problems in cellular mechanobiology.

Kathleen T DiNapoli, Douglas N Robinson, Pablo A Iglesias
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引用次数: 0

Abstract

A cell's ability to change shape is one of the most fundamental biological processes and is essential for maintaining healthy organisms. When the ability to control shape goes awry, it often results in a diseased system. As such, it is important to understand the mechanisms that allow a cell to sense and respond to its environment so as to maintain cellular shape homeostasis. Because of the inherent complexity of the system, computational models that are based on sound theoretical understanding of the biochemistry and biomechanics and that use experimentally measured parameters are an essential tool. These models involve an inherent feedback, whereby shape is determined by the action of regulatory signals whose spatial distribution depends on the shape. To carry out computational simulations of these moving boundary problems requires special computational techniques. A variety of alternative approaches, depending on the type and scale of question being asked, have been used to simulate various biological processes, including cell motility, division, mechanosensation, and cell engulfment. In general, these models consider the forces that act on the system (both internally generated, or externally imposed) and the mechanical properties of the cell that resist these forces. Moving forward, making these techniques more accessible to the non-expert will help improve interdisciplinary research thereby providing new insight into important biological processes that affect human health. This article is categorized under: Cancer > Cancer>Computational Models Cancer > Cancer>Molecular and Cellular Physiology.

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细胞机械生物学中移动边界问题的计算分析工具。
细胞改变形状的能力是最基本的生物过程之一,对于维持生物体的健康至关重要。当控制形状的能力出现问题时,往往会导致系统患病。因此,了解细胞感知环境并做出反应以维持细胞形状平衡的机制非常重要。由于该系统固有的复杂性,基于对生物化学和生物力学的正确理论理解并使用实验测量参数的计算模型是必不可少的工具。这些模型涉及固有的反馈,即形状由调控信号的作用决定,而调控信号的空间分布取决于形状。对这些移动边界问题进行计算模拟需要特殊的计算技术。根据所提问题的类型和规模,有多种替代方法可用于模拟各种生物过程,包括细胞运动、分裂、机械感觉和细胞吞噬。一般来说,这些模型考虑了作用于系统的力(内部产生或外部施加)以及抵抗这些力的细胞机械特性。今后,让非专业人员更容易掌握这些技术将有助于改进跨学科研究,从而为了解影响人类健康的重要生物过程提供新的视角。本文归类于癌症 > 癌症 >计算模型 癌症 > 癌症 >分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
18.40
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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Tools for computational analysis of moving boundary problems in cellular mechanobiology. Cellular reprogramming: Mathematics meets medicine. Thermoregulation: A journey from physiology to computational models and the intensive care unit. Mammalian cell and tissue imaging using Raman and coherent Raman microscopy. Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer.
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