Progress in the design and synthesis of viscosupplements for articular joint lubrication

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2023-08-01 DOI:10.1016/j.cocis.2023.101708
Gavin Gonzales , Stefan Zauscher , Shyni Varghese
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Abstract

Throughout a lifetime, articular joints experience many loading cycles and are prone to mechanical degradation. To safeguard the cartilage in these joints, the synovial fluid acts as a natural lubricant. However, degenerative joint diseases, like osteoarthritis, alter the composition of synovial fluid, diminishing its protective properties. In such cases, exogenous lubricants or viscosupplements can be injected to enhance the compromised synovial fluid's function. Scientists are now developing next-generation viscosupplements, based on hyaluronic acid (HA), that can better bind to and adhere to cartilage. Additionally, non-HA-based viscosupplements offer benefits over HA-based ones, as they possess more intricate molecular architectures, such as dendrimer or bottlebrush-like structures. These viscosupplements draw inspiration from natural molecules present in synovial fluid, providing them with a distinct advantage.

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关节润滑用粘剂的设计与合成研究进展
在整个生命周期中,关节经历了许多加载循环,并且容易发生机械退化。为了保护这些关节的软骨,滑液起到天然润滑剂的作用。然而,退行性关节疾病,如骨关节炎,会改变滑液的成分,降低其保护性能。在这种情况下,可以注射外源性润滑剂或粘剂来增强受损滑液的功能。科学家们目前正在开发下一代以透明质酸(HA)为基础的粘胶补充剂,它可以更好地与软骨结合和粘附。此外,非ha基粘胶剂比ha基粘胶剂更有优势,因为它们具有更复杂的分子结构,如树突状或瓶刷状结构。这些粘补品从滑液中存在的天然分子中汲取灵感,为它们提供了独特的优势。
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来源期刊
CiteScore
16.50
自引率
1.10%
发文量
74
审稿时长
11.3 weeks
期刊介绍: Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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