An evolving view of retinogeniculate transmission.

IF 1.1 4区医学 Q4 NEUROSCIENCES Visual Neuroscience Pub Date : 2017-01-01 DOI:10.1017/S0952523817000104

Elizabeth Y Litvina, Chinfei Chen

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Abstract

The thalamocortical (TC) relay neuron of the dorsoLateral Geniculate Nucleus (dLGN) has borne its imprecise label for many decades in spite of strong evidence that its role in visual processing transcends the implied simplicity of the term "relay". The retinogeniculate synapse is the site of communication between a retinal ganglion cell and a TC neuron of the dLGN. Activation of retinal fibers in the optic tract causes reliable, rapid, and robust postsynaptic potentials that drive postsynaptics spikes in a TC neuron. Cortical and subcortical modulatory systems have been known for decades to regulate retinogeniculate transmission. The dynamic properties that the retinogeniculate synapse itself exhibits during and after developmental refinement further enrich the role of the dLGN in the transmission of the retinal signal. Here we consider the structural and functional substrates for retinogeniculate synaptic transmission and plasticity, and reflect on how the complexity of the retinogeniculate synapse imparts a novel dynamic and influential capacity to subcortical processing of visual information.

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不断发展的视网膜传导观点。

尽管有确凿证据表明，丘脑皮层（TC）在视觉处理中的作用超越了 "中继 "一词所隐含的简单含义，但数十年来，丘脑皮层（TC）背侧膝状突核（dLGN）的中继神经元一直被贴上这个不准确的标签。视网膜神经元突触是视网膜神经节细胞与 dLGN 的 TC 神经元之间进行交流的场所。视束中的视网膜纤维被激活后会产生可靠、快速和强大的突触后电位，从而驱动 TC 神经元中的突触后尖峰。数十年来，人们已经知道皮层和皮层下调节系统可以调节视网膜神经元的传导。视网膜突触本身在发育完善过程中和之后所表现出的动态特性进一步丰富了 dLGN 在视网膜信号传输中的作用。在此，我们探讨了视网膜发生器突触传递和可塑性的结构和功能基质，并思考视网膜发生器突触的复杂性如何为皮层下的视觉信息处理带来了新的动态和影响能力。

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来源期刊

Visual Neuroscience 医学-神经科学

CiteScore

2.20

自引率

5.30%

发文量

审稿时长

>12 weeks

期刊介绍： Visual Neuroscience is an international journal devoted to the publication of experimental and theoretical research on biological mechanisms of vision. A major goal of publication is to bring together in one journal a broad range of studies that reflect the diversity and originality of all aspects of neuroscience research relating to the visual system. Contributions may address molecular, cellular or systems-level processes in either vertebrate or invertebrate species. The journal publishes work based on a wide range of technical approaches, including molecular genetics, anatomy, physiology, psychophysics and imaging, and utilizing comparative, developmental, theoretical or computational approaches to understand the biology of vision and visuo-motor control. The journal also publishes research seeking to understand disorders of the visual system and strategies for restoring vision. Studies based exclusively on clinical, psychophysiological or behavioral data are welcomed, provided that they address questions concerning neural mechanisms of vision or provide insight into visual dysfunction.

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