[Mechanisms of systemic energy metabolism control through gene regulation in skeletal muscle.]

Abstract

Skeletal muscle is the largest tissue in the human body and plays an important role in the regulation of systemic homeostasis and displays remarkable plasticity in their metabolic responses to caloric availability and physical activity. Skeletal muscle maintains muscle mass suitable for the environment according to its own activity state. Skeletal muscles also affect the energy regulation of the whole body by skeletal muscle itself changing muscle fiber composition due to external and internal factors. This review focuses on the transcriptional regulation mechanism of muscle fiber type, which is responsible for overall energy consumption.