[Development of fluorescent probes for bone imaging in vivo ~Fluorescent probes for intravital imaging of osteoclast activity~.]

Clinical calcium Pub Date : 2018-01-01 DOI:CliCa1802187191
Masafumi Minoshima, Kazuya Kikuchi
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Abstract

Fluorescent molecules are widely used as a tool to directly visualize target biomolecules in vivo. Fluorescent probes have the advantage that desired function can be rendered based on rational design. For bone-imaging fluorescent probes in vivo, they should be delivered to bone tissue upon administration. Recently, a fluorescent probe for detecting osteoclast activity was developed. The fluorescent probe has acid-sensitive fluorescence property, specific delivery to bone tissue, and durability against laser irradiation, which enabled real-time intravital imaging of bone-resorbing osteoclasts for a long period of time.

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体内骨成像荧光探针的发展~破骨细胞活性荧光探针的活体成像研究~。
荧光分子作为一种直接观察活体目标生物分子的工具被广泛使用。荧光探针的优点是通过合理的设计,可以实现理想的功能。对于体内骨成像荧光探针,它们应该在给药时传递到骨组织中。近年来,一种检测破骨细胞活性的荧光探针被开发出来。荧光探针具有对酸敏感的荧光特性,对骨组织的特异性递送,以及抗激光照射的耐久性,使骨吸收破骨细胞能够长时间实时活体成像。
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