Chromatin modifications in metabolic disease: Potential mediators of long-term disease risk.

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2018-07-01 Epub Date: 2018-01-25 DOI:10.1002/wsbm.1416
Kevin R Costello, Dustin E Schones
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引用次数: 19

Abstract

Metabolic diseases such as obesity and diabetes are complex diseases resulting from multiple genetic and environmental factors, such as diet and activity levels. These factors are well known contributors to the development of metabolic diseases. One manner by which environmental factors can influence metabolic disease progression is through modifications to chromatin. These modifications can lead to altered gene regulatory programs, which alters disease risk. Furthermore, there is evidence that parents exposed to environmental factors can influence the metabolic health of offspring, especially if exposures are during intrauterine growth periods. In this review, we outline the evidence that chromatin modifications are associated with metabolic diseases, including diabetes and obesity. We also consider evidence that these chromatin modifications can lead to long-term disease risk and contribute to disease risk for future generations. This article is categorized under: Biological Mechanisms > Metabolism Developmental Biology > Developmental Processes in Health and Disease Physiology > Organismal Responses to Environment.

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代谢性疾病中的染色质修饰:长期疾病风险的潜在介质。
肥胖和糖尿病等代谢性疾病是由饮食和活动水平等多种遗传和环境因素引起的复杂疾病。众所周知,这些因素是代谢性疾病发展的原因。环境因素影响代谢性疾病进展的一种方式是通过染色质的修饰。这些修饰可以导致基因调控程序的改变,从而改变疾病风险。此外,有证据表明,父母接触环境因素会影响后代的代谢健康,尤其是在宫内生长期间。在这篇综述中,我们概述了染色质修饰与代谢性疾病相关的证据,包括糖尿病和肥胖症。我们还认为有证据表明,这些染色质修饰会导致长期的疾病风险,并为后代带来疾病风险。本文分类为:生物学机制>代谢发育生物学>健康和疾病生理学中的发育过程>生物对环境的反应。
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来源期刊
CiteScore
18.40
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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