Multiscale systems biology of trauma-induced coagulopathy.

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2018-07-01 Epub Date: 2018-02-27 DOI:10.1002/wsbm.1418
Evan Tsiklidis, Carrie Sims, Talid Sinno, Scott L Diamond
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引用次数: 10

Abstract

Trauma with hypovolemic shock is an extreme pathological state that challenges the body to maintain blood pressure and oxygenation in the face of hemorrhagic blood loss. In conjunction with surgical actions and transfusion therapy, survival requires the patient's blood to maintain hemostasis to stop bleeding. The physics of the problem are multiscale: (a) the systemic circulation sets the global blood pressure in response to blood loss and resuscitation therapy, (b) local tissue perfusion is altered by localized vasoregulatory mechanisms and bleeding, and (c) altered blood and vessel biology resulting from the trauma as well as local hemodynamics control the assembly of clotting components at the site of injury. Building upon ongoing modeling efforts to simulate arterial or venous thrombosis in a diseased vasculature, computer simulation of trauma-induced coagulopathy is an emerging approach to understand patient risk and predict response. Despite uncertainties in quantifying the patient's dynamic injury burden, multiscale systems biology may help link blood biochemistry at the molecular level to multiorgan responses in the bleeding patient. As an important goal of systems modeling, establishing early metrics of a patient's high-dimensional trajectory may help guide transfusion therapy or warn of subsequent later stage bleeding or thrombotic risks. This article is categorized under: Analytical and Computational Methods > Computational Methods Biological Mechanisms > Regulatory Biology Models of Systems Properties and Processes > Mechanistic Models.

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创伤性凝血病的多尺度系统生物学。
创伤伴低血容量性休克是一种极端的病理状态,它在面对出血性失血时挑战机体维持血压和氧合。结合外科手术和输血治疗,患者的生存需要血液维持止血。这个问题的物理学是多尺度的:(a)体循环设定了全球血压,以应对失血和复苏治疗;(b)局部血管调节机制和出血改变了局部组织灌注;(c)创伤导致的血液和血管生物学改变,以及局部血流动力学控制了损伤部位凝血成分的组装。基于正在进行的模拟病变血管中动脉或静脉血栓形成的建模工作,创伤性凝血病的计算机模拟是了解患者风险和预测反应的一种新兴方法。尽管在量化患者的动态损伤负担方面存在不确定性,但多尺度系统生物学可能有助于在分子水平上将血液生化与出血患者的多器官反应联系起来。作为系统建模的一个重要目标,建立患者高维轨迹的早期指标可能有助于指导输血治疗或警告随后的后期出血或血栓形成风险。本文分类如下:分析与计算方法>计算方法生物学机制>系统特性和过程的调控生物学模型>机制模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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