PET/CT and brain MRI role in staging NSCLC: prospective assessment of the accuracy, reliability and cost-effectiveness.

Pub Date : 2018-05-31 eCollection Date: 2018-06-01 DOI:10.2217/lmt-2018-0008

Vasiliki-Konstantina I Gkogkozotou, Ioannis C Gkiozos, Andriani G Charpidou, Elias A Kotteas, Paraskevi G Boura, Sophia N Tsagouli, Konstantinos N Syrigos

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引用次数: 8

Abstract

Aim: To determine whether PET/CT and brain MRI used in staging NSCLC can be accurate, reliable and cost-effective tools. NSCLC represents 80-85% of lung cancer and adequate information on the initial tumor staging is critical for planning an optimal therapeutic strategy.

Patients & methods: Data from 30 newly diagnosed NSCLC patients in Greece were collected and prospectively recorded. Patients with potential resectable disease were evaluated to ensure that there are no detectable metastases that would rule out the possibility of a curative surgery.

Results: Divergence occurred in 50% of cases of staging with CT or PET/CT alone, while metastases undetectable by the CT were revealed using PET/CT. Unnecessary thoracotomies were avoided by 10% of patients and another 10% was operated on after chemotherapy with a better prognosis.

Conclusion: PET/CT and brain MRI combined are reliable for correct staging, reducing avoidable thoracotomies, morbidity rates and costs.

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PET/CT和脑MRI在NSCLC分期中的作用:准确性、可靠性和成本效益的前瞻性评估

目的:确定PET/CT和脑MRI用于NSCLC分期是否准确、可靠和经济。NSCLC占肺癌的80-85%，足够的初始肿瘤分期信息对于制定最佳治疗策略至关重要。患者和方法:收集希腊30例新诊断的非小细胞肺癌患者的数据并进行前瞻性记录。对潜在可切除疾病的患者进行评估，以确保没有可检测到的转移，从而排除治疗性手术的可能性。结果:单独使用CT或PET/CT时，50%的病例出现分期分化，而使用PET/CT时发现了CT未检测到的转移灶。10%的患者避免了不必要的开胸手术，另有10%的患者在化疗后进行了手术，预后较好。结论:PET/CT联合脑MRI可准确分期，减少可避免的开胸手术，降低发病率和费用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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