[Relationship of Executive Functions and Processing Speed with Cortical Gray Matter Morphometry in Healthy Adults and at The Early Stages of Schizophrenia].

Abstract

13 male patients with schizophrenia and 18 age-matched healthy men underwent structural magnetic reso- nance imaging and completed the Stroop task which included the switching condition. As compared to con- trols, the patients showed slowing of color naming in the neutral condition and a reduction ofgray matter vol- ume and thickness in the frontal and temporal areas. In healthy subjects, the time of color naming was neg- atively correlated with gray matter volume in the left cuneus. In the schizophrenia group, there was a positive correlation between the time of color naming and cortical thickness in the middle and inferior frontal gyri of the right hemisphere. These results indicate a change in structural-functional relationships at the early stages of schizophrenia.