[Polymorphisms in Sleep and Cognitive Function Related Genes are Associated with Vehicle Crash History in Shift Working Bus Drivers].

IF 0.2 4区医学 Q4 NEUROSCIENCES Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2017-01-01

V B Dorokhov, A N Puchkova, A O Taranov, V V Ermolayev, T V Tupitsyna, P A Slominsky, V V Dementiyenko

{"title":"[Polymorphisms in Sleep and Cognitive Function Related Genes are Associated with Vehicle Crash History in Shift Working Bus Drivers].","authors":"V B Dorokhov, A N Puchkova, A O Taranov, V V Ermolayev, T V Tupitsyna, P A Slominsky, V V Dementiyenko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Bus driving is a highly responsible profession. It requires constant engagement of attention and cog- nitive resources as well as vigilance and resistance to disruption of sleep- rhythms. There is ongoing research of genetic correlates of these individual characteristics. The aim of this study is to search for possible connections between single nucleotide polymorphisms and the history of road traffic accidents in professional bus driving. 299 professional drives working on rolling shifts with recorded history of traffic accidents took part in the study. Polymorphisms in circadian rhythm-, cognitive and emotional function-related genes were genotyped: CLOCK (rs 12649507), RORA (rs1159814), NPAS2 (rs4851377), NPSR1 (rs324981), PER3 (rs2640909), DRD3 (rs6280), SLC6A3 (rs6347), DBH(rs1611125). Significant associations for polymorphisms in CLOCK, NPSR1 and SLC6A3 with traffic crash parameters were found. We suppose that they are mediated by the difference in chronotype and sleep deprivation resistance for CLOCKand cognitive and emotional control for NPSRI and SLC6A3 polymorphisms.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"67 1","pages":"49-54"},"PeriodicalIF":0.2000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Bus driving is a highly responsible profession. It requires constant engagement of attention and cog- nitive resources as well as vigilance and resistance to disruption of sleep- rhythms. There is ongoing research of genetic correlates of these individual characteristics. The aim of this study is to search for possible connections between single nucleotide polymorphisms and the history of road traffic accidents in professional bus driving. 299 professional drives working on rolling shifts with recorded history of traffic accidents took part in the study. Polymorphisms in circadian rhythm-, cognitive and emotional function-related genes were genotyped: CLOCK (rs 12649507), RORA (rs1159814), NPAS2 (rs4851377), NPSR1 (rs324981), PER3 (rs2640909), DRD3 (rs6280), SLC6A3 (rs6347), DBH(rs1611125). Significant associations for polymorphisms in CLOCK, NPSR1 and SLC6A3 with traffic crash parameters were found. We suppose that they are mediated by the difference in chronotype and sleep deprivation resistance for CLOCKand cognitive and emotional control for NPSRI and SLC6A3 polymorphisms.

微信好友朋友圈 QQ好友复制链接

本刊更多论文

[睡眠和认知功能相关基因多态性与倒班公交司机车祸史相关]。

公共汽车司机是一个高度负责的职业。它需要持续的注意力和认知资源，以及对睡眠节奏中断的警惕和抵抗。目前正在对这些个体特征的遗传相关性进行研究。本研究的目的是寻找单核苷酸多态性与专业巴士驾驶道路交通事故历史之间可能的联系。299名有交通事故记录的职业司机参加了这项研究。昼夜节律、认知和情绪功能相关基因多态性分型:CLOCK (rs 12649507)、RORA (rs1159814)、NPAS2 (rs4851377)、NPSR1 (rs324981)、PER3 (rs2640909)、DRD3 (rs6280)、SLC6A3 (rs6347)、DBH(rs1611125)。发现CLOCK、NPSR1和SLC6A3基因多态性与交通事故参数显著相关。我们认为它们是由时钟型和睡眠剥夺抵抗的差异以及NPSRI和SLC6A3多态性的认知和情绪控制的差异介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊