Combination of Treatments With or Without Surgery in Localized Provoked Vulvodynia: Outcomes After Three Years of Follow-Up.

Q2 Biochemistry, Genetics and Molecular Biology BioResearch Open Access Pub Date : 2019-03-08 eCollection Date: 2019-01-01 DOI:10.1089/biores.2018.0044
Anu Pauliina Aalto, Heini Huhtala, Johanna Mäenpää, Synnöve Staff
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引用次数: 3

Abstract

Most vulvodynia patients receive combinations of several treatment modalities for their chronic painful condition. If conservative treatments fail, vestibulectomy is considered to be the ultimate treatment option for localized provoked vulvodynia (LPV). The aim of this descriptive study was to analyze relief of pain, quality of life (QoL), and complications associated with combining surgery with conservative treatments among LPV patients, both in short term and after 3 years of follow-up. The study population consisted of a retrospective patient cohort of surgically (n = 16) and only conservatively (n = 50) treated LPV patients. QoL data were assessed by a validated questionnaire (RAND-36). Data were collected by reviewing patient records and by aid of postal questionnaires. Efficacy of treatments in relief of pain was measured by numerical rating scale (NRS). Two months after surgery, the NRS scores assessed by a physician were lower in the surgery group than in patients treated only conservatively (p = 0.008). However, after a median of 36 months of follow-up, self-reported NRS scores and QoL showed no difference between the two patient cohorts. Complication rate after vestibulectomy was 18.8%. The findings suggest that combining surgery with conservative treatments may result in a more effective short-term reduction of pain. However, the effect seemed to be only temporary, as no long-term benefit was achieved.

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局部诱发性外阴痛的联合手术治疗:三年随访后的结果。
大多数外阴痛患者接受几种治疗方式的组合为他们的慢性疼痛状况。如果保守治疗失败,前庭切除术被认为是局部诱发性外阴痛(LPV)的最终治疗选择。本描述性研究的目的是分析LPV患者的疼痛缓解、生活质量(QoL)和手术联合保守治疗相关的并发症,包括短期随访和3年随访。研究人群包括回顾性的手术患者队列(n = 16)和仅保守治疗的LPV患者(n = 50)。生活质量数据通过有效问卷(RAND-36)进行评估。通过查阅病人记录和邮寄问卷收集数据。采用数值评定量表(NRS)对治疗后疼痛的缓解效果进行评定。术后2个月,由内科医生评估的手术组NRS评分低于仅接受保守治疗的患者(p = 0.008)。然而,中位随访36个月后,两组患者自我报告的NRS评分和生活质量没有差异。前庭切除术后并发症发生率为18.8%。研究结果表明,手术与保守治疗相结合可能会在短期内更有效地减轻疼痛。然而,这种效果似乎只是暂时的,因为没有取得长期的好处。
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BioResearch Open Access
BioResearch Open Access Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
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期刊介绍: BioResearch Open Access is a high-quality open access journal providing peer-reviewed research on a broad range of scientific topics, including molecular and cellular biology, tissue engineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, virology, and neuroscience. The Journal publishes basic science and translational research in the form of original research articles, comprehensive review articles, mini-reviews, rapid communications, brief reports, technology reports, hypothesis articles, perspectives, and letters to the editor.
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