Solvent retention in electrospun fibers affects scaffold mechanical properties.

Electrospinning Pub Date : 2018-02-01 Epub Date: 2018-09-25 DOI:10.1515/esp-2018-0002
Anthony R D'Amato, Michael T K Bramson, Devan L Puhl, Jed Johnson, David T Corr, Ryan J Gilbert
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引用次数: 20

Abstract

Electrospinning is a robust material fabrication method allowing for fine control of mechanical, chemical, and functional properties in scaffold manufacturing. Electrospun fiber scaffolds have gained prominence for their potential in a variety of applications such as tissue engineering and textile manufacturing, yet none have assessed the impact of solvent retention in fibers on the scaffold's mechanical properties. In this study, we hypothesized that retained electrospinning solvent acts as a plasticizer, and gradual solvent evaporation, by storing fibers in ambient air, will cause significant increases in electrospun fiber scaffold brittleness and stiffness, and a significant decrease in scaffold toughness. Thermogravimetric analysis indicated solvent retention in PGA, PLCL, and PET fibers, and not in PU and PCL fibers. Differential scanning calorimetry revealed that polymers that were electrospun below their glass transition temperature (T g ) retained solvent and polymers electrospun above T g did not. Young's moduli increased and yield strain decreased for solventretaining PGA, PLCL, and PET fiber scaffolds as solvent evaporated from the scaffolds over a period of 14 days. Toughness and failure strain decreased for PGA and PET scaffolds as solvent evaporated. No significant differences were observed in the mechanical properties of PU and PCL scaffolds that did not retain solvent. These observations highlight the need to consider solvent retention following electrospinning and its potential effects on scaffold mechanical properties.

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静电纺丝纤维中的溶剂保留影响支架的机械性能。
静电纺丝是一种稳健的材料制造方法,可以在支架制造中精细控制机械、化学和功能特性。电纺纤维支架因其在组织工程和纺织制造等各种应用中的潜力而备受关注,但没有人评估纤维中溶剂保留对支架机械性能的影响。在这项研究中,我们假设保留的电纺溶剂起到增塑剂的作用,通过将纤维储存在环境空气中,溶剂的逐渐蒸发将导致电纺纤维支架的脆性和刚度显著增加,支架韧性显著降低。热重分析表明溶剂在PGA、PLCL和PET纤维中保留,而在PU和PCL纤维中不保留。差示扫描量热法显示,在低于玻璃化转变温度(Tg)的条件下电纺的聚合物保留了溶剂,而在高于Tg的条件下静电纺的聚合物则没有。当溶剂在14天内从支架上蒸发时,无溶剂的PGA、PLCL和PET纤维支架的杨氏模量增加,屈服应变降低。随着溶剂的蒸发,PGA和PET支架的韧性和失效应变降低。不保留溶剂的PU和PCL支架的机械性能没有观察到显著差异。这些观察结果强调了考虑静电纺丝后溶剂保留及其对支架机械性能的潜在影响的必要性。
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Fabrication and Bioapplications of Magnetically Modified Chitosan-based Electrospun Nanofibers Fabrication of radially aligned electrospun nanofibers in a three-dimensional conical shape Solvent retention in electrospun fibers affects scaffold mechanical properties. Decellularized extracellular matrices for tissue engineering applications Using Electrospun Scaffolds to Promote Macrophage Phenotypic Modulation and Support Wound Healing
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