Single-cell analysis of CD8 T lymphocyte diversity during adaptive immunity.

IF 7.9 Q1 Medicine Wiley Interdisciplinary Reviews-Systems Biology and Medicine Pub Date : 2020-03-01 Epub Date: 2019-12-26 DOI:10.1002/wsbm.1475
Janilyn Arsenio
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引用次数: 2

Abstract

An effective adaptive immune response to microbial infection relies on the generation of heterogeneous T lymphocyte fates and functions. CD8 T lymphocytes play a pivotal role in mediating immediate and long-term protective immune responses to intracellular pathogen infection. Systems-based analysis of the immune response to infection has begun to identify cell fate determinants and the molecular mechanisms underpinning CD8 T lymphocyte diversity at single-cell resolution. Resolving CD8 T lymphocyte heterogeneity during adaptive immunity highlights the advantages of single-cell technologies and computational approaches to better understand the ontogeny of CD8 T cellular diversity following infection. Future directions of integrating single-cell multiplex approaches capitalize on the importance of systems biology in the understanding of immune CD8 T cell differentiation and functional diversity. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates.

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适应性免疫过程中CD8 T淋巴细胞多样性的单细胞分析。
对微生物感染的有效适应性免疫应答依赖于异质T淋巴细胞命运和功能的产生。CD8 T淋巴细胞在介导细胞内病原体感染的即时和长期保护性免疫反应中发挥关键作用。基于系统的感染免疫反应分析已经开始在单细胞分辨率下识别细胞命运决定因素和CD8 T淋巴细胞多样性的分子机制。在适应性免疫过程中解决CD8 T淋巴细胞异质性突出了单细胞技术和计算方法的优势,可以更好地了解感染后CD8 T细胞多样性的个体发生。未来的发展方向是利用系统生物学在理解免疫CD8 T细胞分化和功能多样性方面的重要性。本文分类如下:生理学>哺乳动物健康与疾病生理学生物学机制>细胞命运。
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来源期刊
CiteScore
18.40
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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