The Radiosensitizing Effect of Olanzapine as an Antipsychotic Medication on Glioblastoma Cell.

IF 1.5 4区医学 Q3 PHARMACOLOGY & PHARMACY Current radiopharmaceuticals Pub Date : 2022-01-01 DOI:10.2174/1874471014666210120100448

Seyedeh Zahra Allahgholipour, Soghra Farzipour, Arash Ghasemi, Hossein Asgarian-Omran, Seyed Jalal Hosseinimehr

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引用次数: 2

Abstract

Background: Radiotherapy is used as one of the most effective regimens for cancer treatment, while radioresistance is a major drawback in cancer treatment.

Objectives: This study aimed to evaluate the sensitizing effect of olanzapine (OLA) with X-ray on glioblastoma (U-87 MG) cells death.

Methods: The synergistic killing effect of OLA with ionizing radiation (IR) on glioma was evaluated by colony formation assay. The generations of reactive oxygen species (ROS) and protein carbonyl (PC) as oxidized proteins were determined in OLA-treated and irradiated cells.

Results: Results of this study showed that OLA reduced the number of colonies in irradiated glioma cells.OLA elevated ROS and PC levels in irradiated cells. The synergistic killing effect of OLA with IR in U-87 MG cells was observed at concentrations of 1 μM and 20 μM of OLA. The maximum radiosensitizing effect of OLA was observed at a concentration of 20 μM.

Conclusion: The present study demonstrates that OLA has a radiosensitizing effect on cell death induced by IR in glioma cells.

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奥氮平抗精神病药物对胶质母细胞瘤细胞的放射增敏作用。

背景:放射治疗是最有效的癌症治疗方案之一，而放射耐药是癌症治疗的主要缺点。目的:本研究旨在评价奥氮平(OLA) x射线对胶质母细胞瘤(u - 87mg)细胞死亡的增敏作用。方法:采用集落形成法评价OLA与电离辐射(IR)对胶质瘤的协同杀伤作用。测定了氧化后活性氧(ROS)和蛋白羰基(PC)的代数。结果:本研究结果表明，OLA减少了辐照胶质瘤细胞的菌落数量。OLA提高了辐照细胞的ROS和PC水平。在OLA浓度为1 μM和20 μM时，观察了OLA与IR对U-87 MG细胞的协同杀伤作用。在浓度为20 μM时，OLA的辐射增敏效果最大。结论:本研究表明，OLA对IR诱导的胶质瘤细胞死亡具有放射增敏作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current radiopharmaceuticals PHARMACOLOGY & PHARMACY-

CiteScore

3.20

自引率

4.30%

发文量