External modulators and redox homeostasis: Scenario in radiation-induced bystander cells

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2021-01-01 DOI:10.1016/j.mrrev.2021.108368

Sharmi Mukherjee, Anindita Dutta, Anindita Chakraborty

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引用次数: 7

Abstract

Redox homeostasis is imperative to maintain normal physiologic and metabolic functions. Radiotherapy disturbs this balance and induces genomic instability in diseased cells. However, radiation-induced effects propagate beyond the targeted cells, affecting the adjacent non-targeted cells (bystander effects). The cellular impact of radiation, thus, encompasses both targeted and non-targeted effects. Use of external modulators along with radiation can increase radio-therapeutic efficiency. The modulators’ classification as protectors or sensitizers depends on interactions with damaged DNA molecules. Thus, it is necessary to realize the functions of various radio-sensitizers or radio-protectors in both irradiated and bystander cells. This review focuses on some modulators of radiation-induced bystander effects (RIBE) and their action mechanisms. Knowledge about the underlying signaling cross-talk may promote selective sensitization of radiation-targeted cells and protection of bystander cells.

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外部调节剂和氧化还原稳态:辐射诱导的旁观者细胞的情况

氧化还原稳态是维持正常生理和代谢功能的必要条件。放射治疗会扰乱这种平衡，并在患病细胞中诱发基因组不稳定。然而，辐射诱导的效应会传播到靶细胞之外，影响邻近的非靶细胞(旁观者效应)。因此，辐射对细胞的影响包括目标效应和非目标效应。在放射治疗的同时使用外部调节剂可以提高放射治疗的效率。调节剂作为保护剂或致敏剂的分类取决于与受损DNA分子的相互作用。因此，有必要在被照射细胞和旁观细胞中实现各种辐射敏化剂或辐射保护剂的功能。本文综述了辐射诱导旁观者效应(RIBE)的几种调节剂及其作用机制。了解潜在的信号串扰可能会促进辐射靶向细胞的选择性敏化和对旁观者细胞的保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.