Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression

IF 2.9 4区医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2021-07-29 DOI:10.1007/s00005-021-00625-6

Muhammad Amir Yunus, Muhammad Mahyiddin Ramli, Nurul Huda Osman, Rafeezul Mohamed

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引用次数: 7

Abstract

Sole nanomaterials or nanomaterials bound to specific biomolecules have been proposed to regulate the immune system. These materials have now emerged as new tools for eliciting immune-based therapies to treat various cancers. Graphene, graphene oxide (GO) and reduced GO (rGO) are the latest nanomaterials among other carbon nanotubes that have attracted wide interest among medical industry players due to their extraordinary properties, inert-state, non-toxic and stable dispersion in a various solvent. Currently, GO and rGO are utilized in various biomedical application including cancer immunotherapy. This review will highlight studies that have been carried out in elucidating the stimulation of GO and rGO on selected innate and adaptive immune cells and their effect on cancer progression to shed some insights for researchers in the development of various GO- and rGO-based immune therapies against various cancers.

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用氧化石墨烯和还原氧化石墨烯刺激先天和适应性免疫细胞影响癌症进展

已经提出了单独的纳米材料或与特定生物分子结合的纳米材料来调节免疫系统。这些材料现在已经成为引发基于免疫的治疗各种癌症的新工具。石墨烯、氧化石墨烯（GO）和还原GO（rGO）是其他碳纳米管中最新的纳米材料，由于其非凡的性能、惰性状态、无毒且在各种溶剂中稳定的分散性，吸引了医疗行业参与者的广泛兴趣。目前，GO和rGO被用于各种生物医学应用，包括癌症免疫疗法。这篇综述将重点介绍在阐明GO和rGO对选定的先天和适应性免疫细胞的刺激及其对癌症进展的影响方面所进行的研究，以期为研究人员开发针对各种癌症的各种基于GO和rGO-的免疫疗法提供一些见解。

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来源期刊

Archivum Immunologiae et Therapiae Experimentalis 医学-免疫学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.