Dietary supplementation with casein glycomacropeptide, leucine and tryptophan reduces plasma amino acid levels in men.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2022-04-01 Epub Date: 2021-10-20 DOI:10.1017/neu.2021.34
Erik Roj Larsen, Anette Juel, Erik Jensen, Tristan R Hollyer, Gregers Wegener
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Abstract

Background: The treatment of mania in bipolar disorders needs to be more efficient, as the manic condition creates severe problems for the patient when it comes to work, finances, relationships and health. This proof-of-concept study examines to what extent casein glycomacropeptide (CGMP) may reduce the precursors of dopamine, phenylalanine and tyrosine, in plasma, and therefore be a potential new intervention to treat acute manic episodes.

Method: The study was designed as a double-blind randomised dose-response study of CGMP (with added leucine and tryptophan) in 15 healthy men, receiving 3 different doses of CGMP with an interval of at least 14 days.

Results: Administration of CGMP produced a dose-dependent depletion of plasma aromatic amino acids. The total area under the curve of plasma ratios of phenylalanine-tyrosine compared to the level of leucine-isoleucine-valine--tryptophan was CGMP (20 g): 3.648 [SE:0.3281]; CGMP (40 g): 2.368 [SE:0.1858]; and CGMP (60 g)1.887 [SE:0.2591]. A comparison of the groups showed a dose-dependent statistical difference, with a one-way ANOVA summary (Dunnett) F = 11.87, p = 0.0003, CGMP 20 g versus CGMP 40 g, p = 0.0042, CGMP 20 g versus CGMP 60 g, p = 0.0002. No significant side effects were observed.

Conclusions: This study demonstrate CGMP is a well-tolerated and effective mixture, and that 60 g of CGMP produced the highest depletion of plasma aromatic amino acids (phenylalanine and tyrosine). The effect seems to be highest after 3-4 h. We therefore conclude that this dose should be the one considered for future studies involving CGMP in humans.

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膳食中补充酪蛋白、糖宏肽、亮氨酸和色氨酸可降低男性血浆氨基酸水平。
背景:双相情感障碍患者的躁狂症治疗需要更有效,因为躁狂症在工作、财务、人际关系和健康方面给患者带来了严重的问题。这项概念验证性研究考察了酪蛋白糖宏肽(CGMP)在多大程度上可能减少血浆中多巴胺、苯丙氨酸和酪氨酸的前体,因此可能成为治疗急性躁狂发作的新干预措施。方法:本研究设计为CGMP(添加亮氨酸和色氨酸)的双盲随机剂量-反应研究,在15名健康男性中,接受3种不同剂量的CGMP,间隔至少14天。结果:CGMP使血浆芳香氨基酸呈剂量依赖性耗竭。血浆苯丙氨酸-酪氨酸与亮氨酸-异亮氨酸-缬氨酸-色氨酸比值曲线下总面积为CGMP (20 g): 3.648 [SE:0.3281];CGMP (40 g): 2.368 [SE:0.1858];CGMP (60 g)1.887 [SE:0.2591]。组间比较显示剂量相关的统计学差异,单因素方差分析总结(Dunnett) F = 11.87, p = 0.0003, CGMP 20 g对CGMP 40 g, p = 0.0042, CGMP 20 g对CGMP 60 g, p = 0.0002。未观察到明显的副作用。结论:本研究证明CGMP是一种耐受性良好且有效的混合物,60 g CGMP可产生最高的血浆芳香族氨基酸(苯丙氨酸和酪氨酸)消耗。效果似乎在3-4小时后达到最高。因此,我们得出结论,该剂量应考虑用于未来涉及人体CGMP的研究。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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