Shear Wave Elastography Reveals a High Prevalence of NAFLD-related Fibrosis even in Type 1 Diabetes.

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2022-08-01 Epub Date: 2021-11-16 DOI:10.1055/a-1666-0431

Gesine Meyer, Nina Dauth, Matthias Grimm, Eva Herrmann, Joerg Bojunga, Mireen Friedrich-Rust

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引用次数: 5

Abstract

Background: The association between type 2 diabetes mellitus (T2DM) and advanced stages of non-alcoholic fatty liver disease is well known. Some studies indicate a relevant prevalence also in type 1 diabetes mellitus (T1DM), but so far there is only limited data.

Objective: To determine the prevalence of non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis in individuals with T1DM and compare to those with type 2 diabetes.

Methods: Diabetic patients from a single diabetes care centre were screened for liver fibrosis by sonographic shear wave elastography (SWE). In addition, all patients received laboratory evaluation including non-alcoholic fatty liver fibrosis score and Fibrosis-4 Index.

Results: Three hundred and forty patients were included in the study, of these, 310 received SWE. Overall 254 patients (93 with type 1 and 161 with type 2 diabetes) had reliable measurements and were included in the final analysis. In patients with type 1 diabetes, the prevalence of NAFLD-related liver fibrosis was 16-21%, depending on the method of detection. Significant liver fibrosis was observed in 30-46% of patients with type 2 diabetes.

Conclusions: Our data revealed an unexpectedly high prevalence of NAFLD-related liver fibrosis in patients with type 1 diabetes. To our knowledge, this is one of the first studies using SWE to diagnose advanced NAFLD in type 1 diabetes in a non-preselected cohort. Considering the findings of our study, regular screening for hepatic complications must be recommended for all diabetic patients, even for those with type 1 diabetes.

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横波弹性成像显示即使在1型糖尿病中nafld相关纤维化的高患病率。

背景:2型糖尿病(T2DM)与晚期非酒精性脂肪性肝病之间的关系是众所周知的。一些研究表明，在1型糖尿病(T1DM)中也有相关的患病率，但迄今为止只有有限的数据。目的:确定非酒精性脂肪性肝病(NAFLD)相关肝纤维化在T1DM患者中的患病率，并与2型糖尿病患者进行比较。方法:采用超声剪切波弹性成像(SWE)对某糖尿病护理中心的糖尿病患者进行肝纤维化筛查。此外，所有患者均接受实验室评估，包括非酒精性脂肪性肝纤维化评分和纤维化-4指数。结果:340例患者纳入研究，其中310例接受SWE治疗。总共有254名患者(93名1型糖尿病患者和161名2型糖尿病患者)具有可靠的测量结果，并被纳入最终分析。在1型糖尿病患者中，nafld相关肝纤维化的患病率为16-21%，这取决于检测方法。在30-46%的2型糖尿病患者中观察到明显的肝纤维化。结论:我们的数据显示，在1型糖尿病患者中，nafld相关肝纤维化的患病率出乎意料地高。据我们所知，这是首次在非预选队列中使用SWE诊断1型糖尿病晚期NAFLD的研究之一。考虑到我们的研究结果，必须推荐所有糖尿病患者定期筛查肝脏并发症，即使是1型糖尿病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!