A PDMS-based microneedle array electrode for long-term ECG recording

IF 3 4区 医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2022-08-12 DOI:10.1007/s10544-022-00626-y
Renxin Wang, Jianxin Bai, Xiaohang Zhu, Zhaodong Li, Lixia Cheng, Guojun Zhang, Wendong Zhang
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引用次数: 3

Abstract

To acquire high-quality electrocardiogram (ECG) signals, traditional Ag/AgCl wet electrodes used together with conductive gel can effectively reduce electrode–skin interface impedance (EII) in a short term. However, their weaknesses of poor flexibility and instability can no longer meet the long-term monitoring requirements of intelligent wearable devices. Owing to the flexible dry electrode without conductive gel, it is a good choice to solve the critical problem on drying-out of conductive gel. Therefore, we develop a flexible microneedle array electrode (FMAE) based on polydimethylsiloxane (PDMS) substrate, which obtains reliable bioelectrical signals by way of penetrating into the stratum corneum (SC) of the skin. The fabrication process, including silicon mold, twice PDMS shape-transferring and encapsulation, has advantages of low cost, repeatable production and good biocompatibility. Afterwards, by comparing the performance with different electrodes, impedance test results indicate that the impedance of FMAE are smaller and more stable, and ECG tests in long term and at resting/jogging states also verify that FMAE can obtain durable, stable and reliable signals. In conclusion, FMAE is promising in long-term ECG monitoring.

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一种用于长期心电记录的pdm微针阵列电极
为了获得高质量的心电图信号,传统的Ag/AgCl湿电极与导电凝胶一起使用可以在短期内有效降低电极-皮肤界面阻抗(EII)。但其灵活性差、不稳定等弱点已不能满足智能可穿戴设备的长期监测需求。由于不含导电凝胶的柔性干电极,是解决导电凝胶干燥的关键问题的良好选择。因此,我们开发了一种基于聚二甲基硅氧烷(PDMS)衬底的柔性微针阵列电极(FMAE),该电极通过穿透皮肤角质层(SC)获得可靠的生物电信号。该制备工艺包括硅模、二次PDMS形状转移和封装,具有成本低、可重复生产和良好的生物相容性等优点。随后,通过对比不同电极的性能,阻抗测试结果表明FMAE的阻抗更小、更稳定,长期和静息/慢跑状态下的心电图测试也验证了FMAE可以获得持久、稳定、可靠的信号。综上所述,FMAE在长期心电监测中具有广阔的应用前景。
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来源期刊
Biomedical Microdevices
Biomedical Microdevices 工程技术-工程:生物医学
CiteScore
6.90
自引率
3.60%
发文量
32
审稿时长
6 months
期刊介绍: Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.
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