The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2022-11-04 DOI:10.1017/neu.2022.29
Jaiyeola Abiola Kajero, Soraya Seedat, Jude U Ohaeri, Abidemi Akindele, Oluwagbemiga Aina
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Abstract

Objectives: We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- and long-term administration of haloperidol in a rat model of tardive dyskinesia (TD).

Methods: Haloperidol was administered either sub-chronically via the intraperitoneal (IP) route or chronically via the intramuscular (IM) route to six experimental groups only or in combination with CBD. VCM and oxidative stress parameters were assessed at different time points after the last dose of medication.

Results: Oral CBD (5 mg/kg) attenuated the VCM produced by sub-chronic administration of haloperidol (5 mg/kg) but had minimal effects on the VCM produced by chronic administration of haloperidol (50 mg/kg). In both sub-chronic and chronic haloperidol groups, there were significant changes in brain antioxidant parameters compared with CBD only and the control groups. The sub-chronic haloperidol-only group had lower glutathione activity compared with sub-chronic haloperidol before CBD and the control groups; also, superoxide dismutase, catalase, and 2,2-diphenyl-1-picrylhydrazyl activities were increased in the sub-chronic (IP) haloperidol only group compared with the CBD only and control groups. Nitric oxide activity was increased in sub-chronic haloperidol-only group compared to the other groups; however, the chronic haloperidol group had increased malondialdehyde activity compared to the other groups.

Conclusions: Our findings indicate that CBD ameliorated VCM in the sub-chronic haloperidol group before CBD, but marginally in the chronic haloperidol group before CBD. There was increased antioxidant activity in the sub-chronic group compared to the chronic group.

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大麻二酚对长期服用氟哌啶醇诱导的行为和氧化应激参数的影响。
研究目的方法:在六组实验鼠中,通过腹腔注射(IP)途径或肌肉注射(IM)途径,口服大麻二酚(CBD)对短期和长期氟哌啶醇诱导的空洞咀嚼运动(VCM)和氧化应激参数的影响。在最后一次服药后的不同时间点,对VCM和氧化应激参数进行了评估:结果:口服 CBD(5 毫克/千克)可减轻氟哌啶醇亚慢性给药(5 毫克/千克)产生的 VCM,但对氟哌啶醇慢性给药(50 毫克/千克)产生的 VCM 影响甚微。与只服用 CBD 组和对照组相比,亚慢性和慢性氟哌啶醇组的大脑抗氧化剂参数都发生了显著变化。亚慢性(IP)氟哌啶醇组的谷胱甘肽活性低于亚慢性(CBD前)氟哌啶醇组和对照组;亚慢性(IP)氟哌啶醇组的超氧化物歧化酶、过氧化氢酶和2,2-二苯基-1-苦基肼活性也高于CBD组和对照组。与其他组相比,亚慢性(IP)氟哌啶醇组的一氧化氮活性升高;但与其他组相比,慢性氟哌啶醇组的丙二醛活性升高:我们的研究结果表明,CBD可改善CBD前亚慢性氟哌啶醇组的VCM,但CBD前慢性氟哌啶醇组的VCM则略有改善。与慢性组相比,亚慢性组的抗氧化活性有所提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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