Cobalt-containing borate bioactive glass fibers for treatment of diabetic wound

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2023-08-02 DOI:10.1007/s10856-023-06741-3
Minhui Zhang, Aihua Yao, Fanrong Ai, Jian Lin, Qingge Fu, Deping Wang
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Abstract

Impaired angiogenesis is one of the predominant reasons for non-healing diabetic wounds. Cobalt is well known for its capacity to induce angiogenesis by stabilizing hypoxia-inducible factor-1α (HIF-1α) and subsequently inducing the production of vascular endothelial growth factor (VEGF). In this study, Co-containing borate bioactive glasses and their derived fibers were fabricated by partially replacing CaO in 1393B3 borate glass with CoO. Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance (NMR) analyses were performed to characterize the effect of Co incorporation on the glass structure, and the results showed that the substitution promoted the transformation of [BO3] into [BO4] units, which endow the glass with higher chemical durability and lower reaction rate with the simulated body fluid (SBF), thereby achieving sustained and controlled Co2+ ion release. In vitro biological assays were performed to assess the angiogenic potential of the Co-containing borate glass fibers. It was found that the released Co2+ ion significantly enhanced the proliferation, migration and tube formation of the Human Umbilical Vein Endothelial Cells (HUVECs) by upregulating the expression of angiogenesis-related proteins such as HIF-1α and VEGF. Finally. In vivo results demonstrated that the Co-containing fibers accelerated full-thickness skin wound healing in streptozotocin (STZ)-induced diabetic rat model by promoting angiogenesis and re-epithelialization.

Graphical Abstract

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治疗糖尿病伤口的含钴硼酸盐生物活性玻璃纤维
血管生成障碍是糖尿病创面不愈合的主要原因之一。众所周知,钴通过稳定缺氧诱导因子-1α (HIF-1α)并随后诱导血管内皮生长因子(VEGF)的产生来诱导血管生成。在本研究中,用CoO部分取代1393B3硼酸玻璃中的CaO,制备了含钴硼酸生物活性玻璃及其衍生纤维。傅里叶变换红外光谱(FTIR)和核磁共振(NMR)分析表征了Co加入对玻璃结构的影响,结果表明Co的加入促进了[BO3]向[BO4]单元的转化,使玻璃具有更高的化学耐久性和较低的与模拟体液(SBF)的反应速率,从而实现了Co2+离子的持续和可控释放。体外生物实验评估含钴硼酸玻璃纤维的血管生成潜能。研究发现,释放的Co2+离子通过上调HIF-1α和VEGF等血管生成相关蛋白的表达,显著促进人脐静脉内皮细胞(HUVECs)的增殖、迁移和成管。最后。体内实验结果表明,含钴纤维通过促进血管生成和再上皮化,促进链脲佐菌素(STZ)诱导的糖尿病大鼠模型全层皮肤创面愈合。图形抽象
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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