Fentanyl patch abuse: naloxone complications and extracorporeal membrane oxygenation rescue.

Veterinary and human toxicology Pub Date : 2004-10-01
Anthony F Pizon, Daniel E Brooks
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Abstract

Fentanyl patches offer a novel, but increasingly common method of drug abuse. We describe a patient who developed severe respiratory dysfunction after fentanyl patch abuse via insufflation, naloxone administration and aspiration. After other aggressive interventions failed to correct worsening hypoxemia, extracorporeal membrane oxygenation (ECMO) was initiated and led to complete recovery. To our knowledge, this is the 1st reported case of ECMO being used to correct severe pulmonary dysfunction associated with opioid abuse. The risks associated with naloxone administration are discussed.

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芬太尼贴片滥用:纳洛酮并发症及体外膜氧合抢救。
芬太尼贴片提供了一种新颖但日益普遍的药物滥用方法。我们描述了一位患者在芬太尼贴片滥用后,通过吸入、纳洛酮和吸入产生严重的呼吸功能障碍。在其他积极的干预措施未能纠正恶化的低氧血症后,开始体外膜氧合(ECMO)并导致完全恢复。据我们所知,这是首例报道的ECMO用于纠正与阿片类药物滥用相关的严重肺功能障碍的病例。与纳洛酮管理的风险进行了讨论。
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