Enhanced anti-glioma efficacy of biodegradable periodic mesoporous organosilica nanoparticles through target delivery of chemotherapeutics

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2023-10-04 DOI:10.1007/s10856-023-06747-x
Min Dong, Ying Liu, Biao Liu, Jin Peng, Yuxia Tang, Guangming Lu, Haibin Shi, Feipeng Zhu
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Abstract

Glioma is the most common malignant tumor of the brain and enhancing the efficacy of chemotherapy in glioma is critical for improving patients’ prognosis. In this study, a glioma-targeting drug delivery system is constructed using biodegradable periodic mesoporous organosilica nanoparticles (PMO) that are modified with lactoferrin (Lf) ligands. The obtained PMO is doped with thioether groups and can be degraded in the high concentration of glutathione in tumor cells. The surface area and pore volume of PMO are 772 cm2/g and 0.98 cm3/g, respectively and the loading capacity of doxorubicin (Dox) is as high as 20%. The results of the confocal laser scanning microscope show that the uptake of PMO-Lf@Dox by C6 cells is higher than PMO@Dox. The quantitative analysis of the flow cytometer further demonstrates that more PMO-Lf@Dox enter C6 cells, indicating that the modification of lactoferrin can significantly increase the uptake of C6 cells. Finally, the therapeutic efficacy results show that Lf-modified PMO enhances the inhibitory effect of Dox on C6 cells when incubated for 24 h and 72 h. In summary, this lactoferrin receptor-mediated PMO drug carrier with biodegradability in glutathione in tumor cells can be used to enhance drug delivery into glioma without long-term accumulation in vivo.

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可生物降解的周期性介孔有机硅纳米粒子通过靶向递送化疗药物增强了抗神经胶质瘤的功效。
胶质瘤是最常见的脑恶性肿瘤,提高胶质瘤化疗的疗效对改善患者预后至关重要。在本研究中,使用乳铁蛋白(Lf)配体修饰的可生物降解的周期性介孔有机硅纳米颗粒(PMO)构建了一个神经胶质瘤靶向药物递送系统。所获得的PMO掺杂有硫醚基团,并且可以在肿瘤细胞中的高浓度谷胱甘肽中降解。PMO的表面积和孔隙体积为772 cm2/g和0.98 并且阿霉素(Dox)的负载能力高达20%。共焦激光扫描显微镜的结果表明PMO-Lf@DoxC6细胞的PMO@Dox.流式细胞仪的定量分析进一步表明PMO-Lf@Dox进入C6细胞,表明乳铁蛋白的修饰可以显著增加C6细胞的摄取。最后,疗效结果表明,Lf修饰的PMO在孵育24小时时增强了Dox对C6细胞的抑制作用 h和72 h.总之,这种乳铁蛋白受体介导的PMO药物载体在肿瘤细胞中的谷胱甘肽中具有可生物降解性,可用于增强向神经胶质瘤的药物递送,而无需在体内长期积累。在本研究中,使用乳铁蛋白(Lf)配体修饰的周期性介孔有机硅纳米颗粒(PMO)构建了一个神经胶质瘤靶向药物递送系统。这种乳铁蛋白受体介导的PMO药物载体可用于增强向脑胶质瘤的药物递送。
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来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
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