Regulatory effects and mechanisms of exercise on activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT).

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI:10.1080/21623945.2023.2266147
Haijun Dong, Man Qin, Peng Wang, Shufan Li, Xing Wang
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Abstract

Exercise is a universally acknowledged and healthy way to reducing body weight. However, the roles and mechanisms of exercise on metabolism of adipose tissue remain largely unclear. Adipose tissues include white adipose tissue (WAT), brown adipose tissue (BAT) and beige adipose tissue (BeAT). The main function of WAT is to store energy, while the BAT and BeAT can generate heat and consume energy. Therefore, promotion of BAT activation and WAT browning contributes to body weight loss. To date, many studies have suggested that exercise exerts the potential regulatory effects on BAT activation and WAT browning. In the present review, we compile the evidence for the regulatory effects of exercise on BAT activation and WAT browning and summarize the possible mechanisms whereby exercise modulates BAT activation and WAT browning, including activating sympathetic nervous system (SNS) and promoting the secretion of exerkines, with special focus on exerkines. These data might provide reference for prevention or treatment of obesity and the related metabolic disease through exercise.

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运动对棕色脂肪组织(BAT)活化和白色脂肪组织(WAT)褐变的调节作用及其机制。
运动是一种公认的健康减肥方式。然而,运动对脂肪组织代谢的作用和机制在很大程度上仍不清楚。脂肪组织包括白色脂肪组织(WAT)、棕色脂肪组织(BAT)和米色脂肪组织(BeAT)。WAT的主要功能是储存能量,而BAT和BeAT可以产生热量并消耗能量。因此,促进BAT活化和WAT褐变有助于体重减轻。迄今为止,许多研究表明,运动对BAT激活和WAT褐变具有潜在的调节作用。在这篇综述中,我们收集了运动对BAT激活和WAT褐变的调节作用的证据,并总结了运动调节BAT活化和WAT褐化的可能机制,包括激活交感神经系统(SNS)和促进运动因子的分泌,特别是运动因子。这些数据可为通过运动预防或治疗肥胖及相关代谢疾病提供参考。
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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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