Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours.

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Protein and Peptide Letters Pub Date : 2023-01-01 DOI:10.2174/0929866530666230915103418

Rui Wang, Xia Li, Yangyang Li, Mengjie Zhao, Lida Mi, Weiwei Chen, Jianxiang Song

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Abstract

Estrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignant tumours, both inhibiting the growth of malignant tumours and promoting their development. In addition, the expression level of SULT1E1 may be regulated by a variety of factors, which in turn affect the growth and therapeutic effects of malignant tumours. The aim of this paper is to review the mechanism of action of SULT1E1 in malignant tumours and the mechanisms that are regulated, in order to provide potential targets for the treatment of malignant tumour patients in the future and theoretical support for the realisation of more personalised and effective therapeutic regimens.

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雌激素磺基转移酶SULT1E1在恶性肿瘤中的表达水平和调节因子。

雌激素在许多恶性肿瘤的发展和进展中起着关键作用，雌激素水平的调节涉及多种代谢途径。在这些途径中，雌激素磺基转移酶（SULT1E1）是对雌激素最具亲和力的酶，主要负责催化雌激素硫酸化的代谢反应。相关研究表明，SULT1E1在不同恶性肿瘤中的表达存在显著差异，表明SULT1El在恶性肿瘤中发挥双重作用，既抑制恶性肿瘤的生长，又促进其发展。此外，SULT1E1的表达水平可能受到多种因素的调节，这些因素反过来影响恶性肿瘤的生长和治疗效果。本文的目的是综述SULT1E1在恶性肿瘤中的作用机制及其调控机制，为未来治疗恶性肿瘤患者提供潜在的靶点，并为实现更个性化、更有效的治疗方案提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

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审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis