{"title":"Research status of exosome-derived microRNA in acute myeloid leukemia","authors":"Zhewei He","doi":"10.3760/CMA.J.ISSN.1673-419X.2020.01.005","DOIUrl":null,"url":null,"abstract":"Acute myeloid leukemia (AML) has a high recurrence rate, high case fatality rate and drug resistance, which are major problems to be solved and a research hotspot. A number of researches confirmed that exosome-derived microRNA (miRNA) plays an important role in the disease process, such as the regulation of bone marrow microenvironment, formation of tumor blood vessels in AML, and participating in the occurrence of drug resistance. So for exosome-derived miRNA related researches in AML provide the new research direction to improve the prognosis of patients with AML and overcome drug resistance. The article intends to introduce the related role of exosome-derived miRNA in AML and the drug resistance mechanism of AML mediated by them. \n \n \nKey words: \nLeukemia, myeloid, acute; Exosomes; MicroRNAs; Drug resistance, neoplasm; Tumor microenvironment","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2020.01.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Acute myeloid leukemia (AML) has a high recurrence rate, high case fatality rate and drug resistance, which are major problems to be solved and a research hotspot. A number of researches confirmed that exosome-derived microRNA (miRNA) plays an important role in the disease process, such as the regulation of bone marrow microenvironment, formation of tumor blood vessels in AML, and participating in the occurrence of drug resistance. So for exosome-derived miRNA related researches in AML provide the new research direction to improve the prognosis of patients with AML and overcome drug resistance. The article intends to introduce the related role of exosome-derived miRNA in AML and the drug resistance mechanism of AML mediated by them.
Key words:
Leukemia, myeloid, acute; Exosomes; MicroRNAs; Drug resistance, neoplasm; Tumor microenvironment
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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