{"title":"Research status of bone marrow microenvironment in patients with acute lymphoblastic leukemia","authors":"Zehui Chen, Yueyang Li","doi":"10.3760/CMA.J.ISSN.1673-419X.2020.01.003","DOIUrl":null,"url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is a hematological malignant disease originated from B or T cells. The occurrence and development of ALL are related to the bone marrow microenvironment, which is a complex network system, including osteoblasts, stromal cells, mesenchymal stem cells (MSC), adipose cells, macrophages and regulatory T cells (Treg). The abnormal bone marrow microenvironment formed by the changes of biological characteristics of these cells provides a suitable space for the growth and proliferation of ALL cells. To explore the effect of abnormal bone marrow microenvironment on the occurrence and development of ALL, this review summarizes the advances in the abnormal bone marrow microenvironment of patients with ALL, and interaction between the various related cells and ALL cells. \n \n \nKey words: \nLeukemia; Tumor microenvironment; Bone marrow cells; Stem cell niche; Acute lymphoblastic leukemia; Abnormal bone marrow microenvironment","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"43 1","pages":"12-16"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2020.01.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Acute lymphoblastic leukemia (ALL) is a hematological malignant disease originated from B or T cells. The occurrence and development of ALL are related to the bone marrow microenvironment, which is a complex network system, including osteoblasts, stromal cells, mesenchymal stem cells (MSC), adipose cells, macrophages and regulatory T cells (Treg). The abnormal bone marrow microenvironment formed by the changes of biological characteristics of these cells provides a suitable space for the growth and proliferation of ALL cells. To explore the effect of abnormal bone marrow microenvironment on the occurrence and development of ALL, this review summarizes the advances in the abnormal bone marrow microenvironment of patients with ALL, and interaction between the various related cells and ALL cells.
Key words:
Leukemia; Tumor microenvironment; Bone marrow cells; Stem cell niche; Acute lymphoblastic leukemia; Abnormal bone marrow microenvironment
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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