Effects of parsley (Petroselinum Crispum) hydroalcoholic extract on spermatogenesis and Pituitary- Gonadal axis in streptozotocin- induced diabetic male rat Cheraghi Javad, Kerishchi Khyabani Parisa, Nasri Sima, Zargushi Maryam

Q4 Veterinary Iranian Journal of Veterinary Medicine Pub Date : 2021-08-02 DOI:10.22059/IJVM.2021.312948.1005139

J. Cheraghi, Parisa Kridhchi, S. Nasri, M. Zargooshi

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引用次数: 2

Abstract

AbstractEffects of Parsley (Petroselinum Crispum) Hydroalcoholic Extract on Spermatogenesis and Pituitary- Gonadal Axis in Streptozotocin- Induced Diabetic Male RatBackground: Diabetes mellitus (DM), as a metabolic disease, has a high rate of mortality all over the world. In recent years, there is accumulating evidence that showing this complex multifactorial disease has various effects on reproductive system. Objective: This study aimed to investigate the effect of hydroalcoholic extract of parsley(Petroselinum crispum) leaves on spermatogenesis and pituitary gonadal axis in male streptozotocin (STZ) - induced diabetic ratMethods: In the present study, 60 male rats were divided into 5 groups of 12 animals in each: control, DM control and 3 experimental groups (treated with doses 1g/kg, 2g/kg and 4 g/kg of hydroalcoholic extract of parsley leaves gavage for 28 days). DM was induced intraperitoneal injection of a single dose of STZ (65mg/kg). At the end of the treatment, mice were bled from the heart and follicle-stimulating hormone (FSH), Luteinizing hormone (LH) and testosterones were measured. The testes of mice were isolated and weighted. Results: Comparison of LH, FSH and testosterone in rats treated with doses 1mg/kg of hydro-alcoholic extraction of plant revealed a significant increase as compared the diabetic control group (p <0/05). In addition, the results of histological elucidated that the experimental group (1mg/kg) a significant increase in sperm cells, motility, testis weight, total sperm count relative to diabetic control (P <0.001). Conclusion: It seems that parsley (Petroselinum Crispum) hydroalcoholic extract can be effective in decreasing the reproductive disorders in of DM patient. Key words: Diabetes mellitus, Parsley Medicinal Plants, Rat, Reproductive system, Sex Hormone, spermatogenesis

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香芹水醇提取物对链脲佐菌素诱导的糖尿病雄性大鼠Cheraghi Javad、Kerishchi Khyabani Parisa、Nasri Sima、Zargushi Maryam精子发生和垂体-性腺轴的影响

Parsley（Petroselinum Crispum）水醇提取物对链脲佐菌素诱导的糖尿病雄性大鼠精子发生和垂体-性腺轴的影响背景：糖尿病（DM）作为一种代谢性疾病，在世界范围内死亡率很高。近年来，越来越多的证据表明，这种复杂的多因素疾病对生殖系统有多种影响。目的：研究香芹叶水醇提取物对雄性链脲佐菌素（STZ）诱导的糖尿病大鼠精子发生和垂体-性腺轴的影响。方法：将60只雄性大鼠分为5组，每组12只：对照组，DM对照组和3个实验组（用1g/kg、2g/kg和4g/kg剂量的欧芹叶水醇提取物灌胃处理28天）。诱导DM腹膜内注射单剂量STZ（65mg/kg）。治疗结束时，从小鼠心脏抽血，测量卵泡刺激素（FSH）、促黄体生成素（LH）和睾酮。将小鼠睾丸分离并称重。结果：与糖尿病对照组相比，1mg/kg植物水醇提取物处理大鼠的LH、FSH和睾酮水平显著升高（p＜0.05）。此外，组织学结果表明，实验组（1mg/kg）与糖尿病对照组相比，精子细胞、活力、睾丸重量、精子总数均显著增加（P＜0.001）。关键词：糖尿病，Parsley药用植物，大鼠，生殖系统，性激素，精子发生

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